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47612

Sigma-Aldrich

Folinic acid calcium salt hydrate

BioXtra, ≥99.0% (HPLC)

Synonym(s):

5-Formyl-5,6,7,8-tetrahydrofolic acid calcium salt, 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid calcium salt, 5-HCO-H4PteGlu, Calcium folinate, Citrovorum factor calcium salt, Leucovorin calcium salt

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1 ML
¥846.49
10 ML
¥4,233.78
25 ML
¥5,406.04
100 ML
¥17,320.49
500 ML
¥70,141.54

¥846.49

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1 ML
¥846.49
10 ML
¥4,233.78
25 ML
¥5,406.04
100 ML
¥17,320.49
500 ML
¥70,141.54

About This Item

Empirical Formula (Hill Notation):
C20H21CaN7O7 · xH2O
CAS Number:
1492-18-8
Molecular Weight:
511.50 (anhydrous basis)
Beilstein:
5723924
MDL number:
MFCD00149463
UNSPSC Code:
12352106
PubChem Substance ID:
24871209
NACRES:
NA.28

¥846.49

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biological source

synthetic

Quality Level

200

product line

BioXtra

Assay

≥99.0% (HPLC)

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

color

white to faint yellow

mp

240-250 °C

application(s)

cell analysis

SMILES string

[Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13

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Show Differences

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This Item
P6611H8162P9740
HIS-Select® HF Nickel Affinity Gel

H0537

HIS-Select® HF Nickel Affinity Gel

HIS-Select® Nickel Affinity Gel (1:1 suspension in a 20% ethanol solution)

P6611

HIS-Select® Nickel Affinity Gel

HIS-Select® Cobalt Affinity Gel (1:1 suspension in a 30% ethanol solution)

H8162

HIS-Select® Cobalt Affinity Gel

PHOS-Select™ Iron Affinity Gel

P9740

PHOS-Select™ Iron Affinity Gel

capacity

15 mg/mL, gel binding capacity (protein)(with an approx. 30 kDa protein)

capacity

>15 mg/mL, gel binding capacity (protein)(with an approx. 30 kDa protein)

capacity

>15 mg/mL, agarose binding capacity (protein)(with an approx. 30 kDa protein)

capacity

≥2 μmol/mL, gel (phosphopeptide)(following a 30 minute incubation at 25°C)

technique(s)

affinity chromatography: suitable

technique(s)

protein purification: suitable

technique(s)

protein purification: suitable

technique(s)

-

form

suspension

form

(1:1 suspension in a 20% ethanol solution)

form

(1:1 suspension in a 30% ethanol solution)

form

suspension

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

General description

Calcium salt of the (6R,S)-mixture of diastereomers of 5-formyl-5,6,7,8-tetrahydrofolate.
Folinic acid, also called as calcium leucovorin, is usually available as an amorphous powder and lacks odor.[1] This activated form of vitamin B9[2] is off-white to light beige in color.[1] Folic acid (FA) is a water-soluble vitamin. Folinic acid is the 5-formyl derivative of tetrahydrofolic acid and is the reduced form of folic acid.[3]

Application

Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Folinic acid calcium salt hydrate has been used in the preparation of topical 1% and 2.5% folinic acid creams for use in wound healing studies.[4] It has also been used as a component in the chemically defined-Chinese hamster ovary medium (CD-CHO) to culture CHO DUKX B11.[5]

Biochem/physiol Actions

Folinic acid serves as a cofactor and participates in one-carbon-transfer reactions.[2] It helps in improving wound healing in rats.[4] Folinic acid plays a major role in children with autism to enhance verbal communication.[6]

Other Notes

Review[7]

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H317,H319,H334,H335

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM9050
    BCCH6795
    BCCK6285
    BCCC9553
    BCBX6874

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    Calcium Leucovorin
    Analytical Profiles of Drug Substances, 8, 315-350 (1979)
    OPP Labeling Enables Total Protein Synthesis Quantification in CHO Production Cell Lines at the Single-Cell Level
    Nagelreiter F, et al.
    Biotechnology Journal, 13(4), 1700492-1700492 (2018)
    Nutritional Regulation of Mitochondrial Function
    Mitochondria, 93-126 (2019)
    L.O. Pont et al.
    Anal. Profiles Drug Subst., 8, 315-315 (1979)
    Topical folinic acid enhances wound healing in rat model
    Duman N, et al.
    Advances in Medical Sciences, 63(2), 347-352 (2018)
    View All Related Papers

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    Chromatograms

    application for HPLCapplication for HPLC

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