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Q5001

Quinidine gluconate salt

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C20H24N2O2 · C6H12O7
CAS Number:
7054-25-3
Molecular Weight:
520.57
NACRES:
NA.24
PubChem Substance ID:
329823867
UNSPSC Code:
41116107
EC Number:
230-333-9
MDL number:
MFCD00067566

Key Documents

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InChI key

XHKUDCCTVQUHJQ-LCYSNFERSA-N

InChI

1S/C20H24N2O2.C6H12O7/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;7-1-2(8)3(9)4(10)5(11)6(12)13/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;2-5,7-11H,1H2,(H,12,13)/t13-,14-,19+,20-;2-,3-,4+,5-/m01/s1

SMILES string

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.[H][C@@]12CCN(C[C@@H]1C=C)[C@]([H])(C2)[C@@H](O)c3ccnc4ccc(OC)cc34

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

application(s)

food and beverages

format

neat

Quality Level

100

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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D Darbar et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 53(6), 655-658 (1996-03-15)
The effect of a polyvinyl chloride (PVC) i.v. administration system on the availability of quinidine gluconate was studied. Quinidine gluconate diluted in 5% dextrose injection was administered intravenously to five healthy volunteers via conventional PVC infusion sets, and the subjects
K D Miller et al.
The New England journal of medicine, 321(2), 65-70 (1989-07-13)
During the past decade the incidence of Plasmodium falciparum malaria in the United States has increased 10-fold. Treatment may be delayed because the therapy recommended for severe or complicated disease, intravenous quinine dihydrochloride, is available only from the Centers for
P T Holzberger et al.
American heart journal, 136(1), 49-56 (1998-07-17)
Intravenous procainamide hydrochloride is frequently used in the acute care setting and during electrophysiologic testing, but intravenous quinidine gluconate is rarely used because of concerns about its safety. This study prospectively compares the hemodynamic and electrophysiologic effects of these agents
A Garg et al.
Journal of cardiovascular electrophysiology, 9(6), 642-647 (1998-07-08)
A case is presented of an 18-year-old male who had been resuscitated following an episode of sudden death due to ventricular fibrillation. The patient was noted to have an abnormal deflection in the terminal QRS on surface ECG and an
Proarrhythmia: disparity of programmed electrical stimulation results and spontaneous occurrence: a case report.
A E Alicea et al.
Maryland medical journal (Baltimore, Md. : 1985), 40(6), 521-523 (1991-06-01)
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