PHR1257
Lidocaine hydrochloride
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Lidocaine hydrochloride monohydrate, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate, Lignocaine hydrochloride monohydrate, Xylocaine hydrochloride monohydrate
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About This Item
Empirical Formula (Hill Notation):
C14H22N2O · HCl · H2O
CAS Number:
Molecular Weight:
288.81
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
grade
certified reference material
pharmaceutical secondary standard
Quality Level
Agency
traceable to BP 214
traceable to Ph. Eur. L0600000
traceable to USP 1366013
API family
lidocaine
CofA
current certificate can be downloaded
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
Cl[H].[H]O[H].CCN(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
InChI key
YECIFGHRMFEPJK-UHFFFAOYSA-N
Gene Information
human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)
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General description
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Lidocaine hydrochloride is an amide type local anaesthetic that belongs to the class of 1b antiarrhythmics. It is used for regional nerve blocks and infiltrative administration of anaesthesia. It prevents the entry of sodium ions into nerve endings, at the site of pain, and disrupts the electrical signal from reaching the brain.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Lidocaine hydrochloride is an amide type local anaesthetic that belongs to the class of 1b antiarrhythmics. It is used for regional nerve blocks and infiltrative administration of anaesthesia. It prevents the entry of sodium ions into nerve endings, at the site of pain, and disrupts the electrical signal from reaching the brain.
Application
This pharmaceutical secondary standard can also be used as follows:
- Sensitive determination of lidocaine hydrochloride and cetylpyridinium chloride in their binary mixtures in different pharmaceutical formulations by three spectrophotometric-based methods
- Simultaneous analysis of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation by high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC)-densitometric methods
- Quantification of ceftriaxone sodium and lidocaine HCl in human plasma samples by high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS)
- Quantitative analysis of lidocaine hydrochloride and miramistin in a wound healing gel sample by high-performance liquid chromatography (HPLC) combined with UV detection
- Development of a method based on liquid–liquid extraction of nifedipine and lidocaine hydrochloride from human plasma samples for their subsequent analysis by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS)
- Dispersive liquid-liquid microextraction (DLLME) followed by attenuated total reflectance-Fourier transform infrared measurement of dry films for the determination of lidocaine hydrochloride in human urine sample
Biochem/physiol Actions
Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration
Analysis Note
These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.
Footnote
To see an example of a Certificate of Analysis for this material enter LRAB3669 in the slot below. This is an example certificate only and may not be the lot that you receive.
Recommended products
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Lories I Bebawy et al.
Journal of chromatographic science, 54(4), 492-499 (2015-12-17)
Two sensitive and selective analytical methods were developed for simultaneous determination of aminoacridine hydrochloride and lidocaine hydrochloride in bulk powder and pharmaceutical formulation. Method A was based on HPLC separation of the cited drugs with determination of the toxic lidocaine-related
George A Spirou et al.
eLife, 12 (2023-06-08)
Globular bushy cells (GBCs) of the cochlear nucleus play central roles in the temporal processing of sound. Despite investigation over many decades, fundamental questions remain about their dendrite structure, afferent innervation, and integration of synaptic inputs. Here, we use volume
Development and Validation of a Method for Determining Lidocaine Hydrochloride and Miramistin in an Innovative Wound-Healing Gel
Brkich LL, et al.
Pharmaceutical Chemistry Journal, 54, 69-72 (2020)
Shaun Mehta et al.
JAMA facial plastic surgery, 16(6), 414-418 (2014-09-12)
This study evaluates the postoperative outcomes achieved with incisionless otoplasty for the correction of prominauris. To determine whether incisionless otoplasty is a reliable and replicable technique in correcting prominauris. This study consisted of a retrospective electronic medical record review for
Fang-Chi Yang et al.
Neurobiology of learning and memory, 112, 186-194 (2013-07-31)
Learning active or reactive responses to fear involves different brain circuitry. This study examined how the nuclus accumbens (NAc), dorsal hippocampus (DH) and medial prefrontal cortex (mPFC) may interact in memory processing for these two kinds of responses. Male Wistar
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