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PHR1252

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Procainamide hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride, 4-Aminobenzoic acid 2-diethylaminoethylamide

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About This Item

Linear Formula:
H2NC6H4CONHCH2CH2N(C2H5)2·HCl
CAS Number:
614-39-1
Molecular Weight:
271.79
Beilstein:
3729517
EC Number:
210-381-7
MDL number:
MFCD00012998
UNSPSC Code:
41116107
PubChem Substance ID:
329823255
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. P3050000
traceable to USP 1563502

API family

procainamide

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

167-169 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl.CCN(CC)CCNC(=O)c1ccc(N)cc1

InChI

1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H

InChI key

ABTXGJFUQRCPNH-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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General description

Procainamide hydrochloride belongs to the class I of antiarrhythmic drugs and is used for the management of heart arrhythmia in cardiac patients. It is also proposed to exhibit chemoprotective behavior against cisplatin-induced kidney toxicity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Procainamide hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by spectrophotometric and electrophoretic techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC4012 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD5018
LRAD6121
LRAC4012
P500252
LRAA9056

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If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

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Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats
Zicca A, et al.
European Journal of Pharmacology, 442(3), 265-272 (2002)
Spectrophotometric determination of procainamide hydrochloride using sodium periodate
Al-Tamrah S and Al-Abbad,S
Arabian Journal of Chemistry, 8(5), 609-613 (2015)
Spectrophotometric determination of nicoumalone, acebutolol hydrochloride and procainamide hydrochloride
Sastry CSP, et al.
Talanta, 38(9), 1057-1060 (1991)
Z Wojnarowska et al.
The Journal of chemical physics, 136(16), 164507-164507 (2012-05-09)
The pharmaceuticals, procaine hydrochloride and procainamide hydrochloride, are glass-forming as well as ionically conducting materials. We have made dielectric measurements at ambient and elevated pressures to characterize the dynamics of the ion conductivity relaxation in these pharmaceuticals, and calorimetric measurements
Malyaj Narwaley et al.
Chemical research in toxicology, 24(7), 1031-1039 (2011-06-16)
Aromatic amine drugs like aminoglutethimide (AG) and related congeners have been shown to produce phenyl radicals through metabolism by myeloperoxidase (MPO)/H(2)O(2), which has been proposed to play a role in drug-induced agranulocytosis. AG has also been shown to induce MPO
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