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Merck
CN

P4554

Proparacaine hydrochloride

analytical standard

Synonym(s):

Proxymetacaine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H26N2O3 · HCl
CAS Number:
Molecular Weight:
330.85
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
227-541-7
MDL number:
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InChI key

BFUUJUGQJUTPAF-UHFFFAOYSA-N

InChI

1S/C16H26N2O3.ClH/c1-4-10-20-15-8-7-13(12-14(15)17)16(19)21-11-9-18(5-2)6-3;/h7-8,12H,4-6,9-11,17H2,1-3H3;1H

SMILES string

Cl.CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC

grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

Quality Level

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General description

Proparacaine hydrochloride is a topical ocular anesthetic, which is commonly used in pediatric patients.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Topical ophthalmic anesthetic

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Certificates of Analysis (COA)

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X Sun et al.
Acta paediatrica (Oslo, Norway : 1992), 99(3), 329-334 (2009-12-05)
To assess whether non-pharmacological and/or pharmacological measures lead to decreased pain during an eye examination in preterm infants. . Systematic review. Premature infants meeting the criteria for screening eye examination for retinopathy. Databases were searched through the Ovid interface. Randomized
Applied Pharmacology for Veterinary Technicians (2009)
Miriam L Conway et al.
Journal of cataract and refractive surgery, 36(2), 268-272 (2010-02-16)
To evaluate blood-flow responses before and after microkeratome application. School of Life and Health Sciences, Aston University, Birmingham, United Kingdom. Hemodynamic responses were measured in eyes of healthy volunteers before and after transient elevation in intraocular pressure (IOP) resulting from
M Mehta et al.
Journal of perinatology : official journal of the California Perinatal Association, 30(11), 731-735 (2010-03-20)
The efficacy of topical anesthesia during retinopathy of prematurity (ROP) screening has been a controversial issue. To determine the efficacy of proparacaine eye drops (0.5%), we compared the Premature Infant Pain Profile (PIPP) scores in 40 preterm infants undergoing ROP
Mani Baskaran et al.
Investigative ophthalmology & visual science, 55(11), 7669-7673 (2014-10-23)
To evaluate a novel software capable of automatically grading angle closure on EyeCam angle images in comparison with manual grading of images, with gonioscopy as the reference standard. In this hospital-based, prospective study, subjects underwent gonioscopy by a single observer

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