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Merck
CN

69480

N-Methyl-N-trimethylsilylacetamide

derivatization grade (GC derivatization), LiChropur™, ≥97.0% (GC)

Synonym(s):

MSA

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About This Item

Empirical Formula (Hill Notation):
C6H15NOSi
CAS Number:
7449-74-3
Molecular Weight:
145.27
UNSPSC Code:
23151816
NACRES:
NA.22
PubChem Substance ID:
329761691
EC Number:
231-217-0
Beilstein/REAXYS Number:
506975
MDL number:
MFCD00040758

Key Documents

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InChI key

QHUOBLDKFGCVCG-UHFFFAOYSA-N

InChI

1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3

SMILES string

CN(C(C)=O)[Si](C)(C)C

grade

derivatization grade (GC derivatization)

assay

≥97.0% (GC)

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.439

bp

159-161 °C (lit.)

density

0.904 g/mL at 20 °C (lit.)

storage temp.

−20°C

Quality Level

100

General description

N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).

Application

N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:       
  • Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.       
  • Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.

Other Notes

Powerful silylating agent for polar compounds

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Flame
GHS02

signalword

Warning

hcodes

H226

Hazard Classifications

Flam. Liq. 3

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

118.4 °F - closed cup

flash_point_c

48.0 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCB7757

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Jesse Elias et al.
PLoS medicine, 15(5), e1002562-e1002562 (2018-05-02)
Tobacco addiction is a complex, multicomponent phenomenon stemming from nicotine's pharmacology and the user's biology, psychology, sociology, and environment. After decades of public denial, the tobacco industry now agrees with public health authorities that nicotine is addictive. In 2000, Philip
Sample derivatization in separation science
Analytical separation science (2015)
Damaged products of thymine in hydroxyl radical solution under UV irradiation
Hong J, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 63(1), 109-118 (1999)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
M. Donike
Journal of Chromatography A, 103, 91-91 (1975)
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