Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

69479

Supelco

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

derivatization grade (GC derivatization), LiChropur™, ≥98.5%

Synonym(s):

N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA

Sign Into View Organizational & Contract Pricing

Select a Size

5 ML
CN¥1,541.27
10 X 1 ML
CN¥2,460.67
25 ML
CN¥4,616.17

CN¥1,541.27

Available to ship onApril 27, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 ML
CN¥1,541.27
10 X 1 ML
CN¥2,460.67
25 ML
CN¥4,616.17

About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
24589-78-4
Molecular Weight:
199.25
Beilstein:
1941550
EC Number:
246-331-6
MDL number:
MFCD00000411
UNSPSC Code:
23151817
PubChem Substance ID:
329761689
NACRES:
NA.22

CN¥1,541.27

Available to ship onApril 27, 2025Details

Request a Bulk Order

grade

derivatization grade (GC derivatization)

Quality Level

200

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

Assay

≥98.5% (GC)
≥98.5%

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.38 (lit.)
n20/D 1.380

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
69478M7891394866
N-Methyl-N-(trimethylsilyl)trifluoroacetamide derivatization grade (GC derivatization), LiChropur™, ≥98.5%

69479

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane derivatization grade (GC derivatization), LiChropur™

69478

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur™

M7891

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-(trimethylsilyl)trifluoroacetamide synthesis grade

394866

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

assay

≥98.5% (GC)

assay

≥97.0%

assay

-

assay

≥98%

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

-

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

bp

130-132 °C (lit.)

bp

-

bp

130-132 °C (lit.)

bp

130-132 °C (lit.)

form

liquid

form

liquid

form

liquid

form

liquid

density

1.075 g/mL at 25 °C (lit.)

density

-

density

1.07 g/mL at 25 °C (lit.), 1.075 g/mL at 25 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a silylating reagent.[1]

Application

Learn more in the Product Information
MSTFA may be used in silylation procedure to detemine steroid hormones 17α-ethinylestradiol (EE2) and estrone using GC-MS. MSTFA along with Trimethylsilyl chloride (TMCS) in eithyl acetate, acetonitrile and dichloromethane solvents leads to formation of trimethylsilyl (TMS) and tert-butyldimethylsilyl (TBS) derivatives.[1]
Suitable for the derivatization of amines, amino acids, carboxyl, hydroxyamines, indolalkylamine, n-nitrosoamino acids, nucleosides, phenolalkylamines, serotonin and tryptamine.

Other Notes

Powerful silylating agent[2][3][4][5]
Reagent for N-acetyl-N, trifluoroacetyl, trimethylsilyl, N-trimethylsilyl-N-trifluoroacetyl, and O-trimethylsilyl (TMS)

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

77.0 °F - closed cup

Flash Point(C)

25 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM9951
    BCCM8642
    BCCL7103
    BCCK5146
    BCCH1152

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    J. Heberle et al.
    Silylating Agents, 2nd ed. (1995)
    Journal of Chromatography A, 115, 591-591 (1975)
    M. Donike
    Chromatographia, 9, 440-440 (1976)
    Hieng-Ming Ting et al.
    Frontiers in plant science, 11, 257-257 (2020-03-27)
    Glucosinolates are defense-related secondary metabolites found in Brassicaceae. When Brassicaceae come under attack, glucosinolates are hydrolyzed into different forms of glucosinolate hydrolysis products (GHPs). Among the GHPs, isothiocyanates are the most comprehensively characterized defensive compounds, whereas the functional study of
    Chanhee Jo et al.
    Experimental & molecular medicine, 52(12), 2005-2019 (2020-12-15)
    Acetylation is the most studied histone acyl modification and has been recognized as a fundamental player in metabolic gene regulation, whereas other short-chain acyl modifications have only been recently identified, and little is known about their dynamics or molecular functions
    View All Related Papers

    Articles

    Fatty Acid Methyl Ester analysis by Gas Chromatography

    Development and validation of a fatty acid methyl esterification method, using methanolic HCl reagent, for FAME analysis by GC of vegetable oils and fats.

    Silylation of Non-Steroidal Anti-Inflammatory Drugs

    Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

    Protocols

    MSTFA/MSTFA-d9 Derivatization of Amphetamine for GC/MS Detection and Identification

    Example displays how MSTFA/MSTFA-d9 derivatization of amphetamine provides valuable information in mass spectra and chromatograms using SLB-5ms GC column.

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service