Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
All Photos(1)

Key Documents

View All Documentation

Safety Information

69478

Supelco

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

with 1% trimethylchlorosilane, for GC derivatization, LiChropur™

Sign Into View Organizational & Contract Pricing

Select a Size

1 ML
CN¥736.34
5 ML
CN¥2,918.48
10 X 1 ML
CN¥7,883.24

CN¥736.34

Available to ship onApril 14, 2025Details

Request a Bulk Order
All Photos(1)

Select a Size

Change View
1 ML
CN¥736.34
5 ML
CN¥2,918.48
10 X 1 ML
CN¥7,883.24

About This Item

Empirical Formula (Hill Notation):
C6H12F3NOSi
CAS Number:
24589-78-4
Molecular Weight:
199.25
Beilstein:
1941550
MDL number:
MFCD00000411
UNSPSC Code:
23151817
PubChem Substance ID:
329761687
NACRES:
NA.22

CN¥736.34

Available to ship onApril 14, 2025Details

Request a Bulk Order

Product Name

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane, LiChropur™

grade

derivatization grade ((GC derivatization))

Quality Level

100

Assay

≥97.0%

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

technique(s)

gas chromatography (GC): suitable

refractive index

n20/D 1.378

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

Related Categories

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
M789112124841102
N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane LiChropur™

69478

N-Methyl-N-(trimethylsilyl)trifluoroacetamide with 1% trimethylchlorosilane

N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur™

M7891

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

N-Methyl-N-trimethylsilyltrifluoroacetamide activated III LiChropur™, activated with imidazole

12124

N-Methyl-N-trimethylsilyltrifluoroacetamide activated III

N-Methyl-N-trimethylsilyl-trifluoroacetamide for synthesis

841102

N-Methyl-N-trimethylsilyl-trifluoroacetamide

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

-

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

form

liquid

form

liquid

form

-

form

liquid

refractive index

n20/D 1.378

refractive index

n20/D 1.38 (lit.)

refractive index

n20/D 1.383

refractive index

-

grade

for GC derivatization

grade

-

grade

for GC derivatization

grade

-

General description

Silylation can be performed by adding N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MTFA) during analysis of fluorometabolites via gas chromatography-mass spectrometry (GC-MS).[1]

Application

Addition of Trimethylchlorosilane aids in the derivatization of amides, secondary amines and hindered hydroxy groups. Most volatile of the TMS derivatives often elutes at the solvent front of the GC.

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Warning

Hazard Statements

H226,H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

78.8 °F - closed cup

Flash Point(C)

26 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

危险化学品
  • Specification Sheet

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCL2549
    BCCG9280
    BCCJ5812
    BCCF5955
    BCCC9855

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Filamentous fungal biofilm for production of human drug metabolites.
    Amadio, Jessica, Eoin Casey, and Cormac D. Murphy.
    Applied Microbiology and Biotechnology, 97 (13), 5955-5963 (2013)
    Hee-Kyung Jeon et al.
    Journal of chromatography. A, 1131(1-2), 192-202 (2006-08-08)
    A novel method has been developed to simultaneously determine and quantify seven organic UV filters employing liquid (solid)-liquid extraction, derivatization with N-methyl-N-(trimethylsilyl) trifluoroacetamide (MSTFA) and gas chromatography with mass spectrometric detection in various environmental matrices. The UV filters determined were:
    Harin Kanani et al.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 871(2), 191-201 (2008-06-10)
    Metabolomics being the most recently introduced "omic" analytical platform is currently at its development phase. For the metabolomics to be broadly deployed to biological and clinical research and practice, issues regarding data validation and reproducibility need to be resolved. Gas
    John A Bowden et al.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877(27), 3237-3242 (2009-08-21)
    Steroid derivatization was investigated by varying the experimental parameters (reagent, reaction time, and reaction temperature) to determine the optimal conditions for individual steroids, and for larger subsets. Three methods of derivatization enhancement were also investigated: the use of sonication, the
    Iria González-Mariño et al.
    Journal of chromatography. A, 1217(11), 1748-1760 (2010-02-13)
    An alternative method for the sensitive determination of several drugs of abuse and some of their metabolites in surface and sewage water samples is proposed. Analytes are concentrated using a solid-phase extraction (SPE) sorbent, converted into the corresponding trimethylsilyl derivatives
    View All Related Papers

    Articles

    Silylation of Non-Steroidal Anti-Inflammatory Drugs

    Results of a study involving the ability few Fluka silylating reagents to form GC-MS-compatible trimethylsilylmethyl derivatives of NSAIDs

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service