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420119

Sigma-Aldrich

SP600125

≥98% (HPLC), solid, JNK inhibitor, Calbiochem®

Synonym(s):

JNK Inhibitor II, SAPK Inhibitor II, Anthra[1,9- cd]pyrazol-6(2 H)-one, 1,9-pyrazoloanthrone, SP600125

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About This Item

Empirical Formula (Hill Notation):
C14H8N2O
CAS Number:
129-56-6
Molecular Weight:
220.23
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

JNK Inhibitor II, JNK Inhibitor II. SP600125, CAS 129-56-6, is a potent, cell-permeable, selective, and ATP competitive inhibitor of c-Jun N-terminal kinase (JNK; IC₅₀ = 40 nM for JNK-1 & JNK-2 & 90 nM for JNK-3).

Quality Level

200

description

RTECS - CB4585000

Assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow-orange

solubility

DMSO: 15 mg/mL

shipped in

ambient

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product line

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product line

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product line

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product line

SpheriCal™

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care

form

solid

form

solid

form

solid

form

solid

shelf life

expiry date on the label

shelf life

expiry date on the label

shelf life

expiry date on the label

shelf life

expiry date on the label

mol wt

Mr 500-1600 Da (Na+-adduct)

mol wt

Mr 7500-15000 Da (Na & adduct)

mol wt

Mr 1600-3500 Da (Na & adduct)

mol wt

Mr 3500-7500 Da (Na+-adduct)

General description

A potent, cell-permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3). The inhibition is competitive with respect to ATP. Exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38-2 MAP kinases. Inhibits the phosphorylation of c-Jun and blocks cellular expression of IL-2, IFN-γ, TNF-α, and COX-2. Blocks IL-1-induced accumulation of phospho-Jun and induction of c-Jun transcription. A 50 mM (5 mg/454 µl) solution of JNK Inhibitor II (Cat. No. 420128) in DMSO is also available.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
JNK 1, JNK 2, JNK 3
Product competes with ATP.
Reversible: yes
Target IC50: 40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Preparation Note

For every 10 µM concentration of JNK Inhibitor II, include 0.1% DMSO in the culture medium. Pre-warming of culture medium and addition of BSA to the medium may enhance its solubility.

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 2 months at -20°C.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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