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形式
solid
质量水平
颜色
yellow
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI key
QFWCYNPOPKQOKV-UHFFFAOYSA-N
基因信息
human ... MAP2K1(5604) , MAP2K2(5605) , MAP2K3(5606) , MAP2K4(6416) , MAP2K5(5607) , MAP2K6(5608) , MAP2K7(5609) , MAP3K1(4214) , RAF1(5894)
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应用
PD 98,059已用于：
- 生长培养基,作为有丝分裂原活化蛋白（MAP）激酶抑制剂，以研究与D1样受体作用有关的次级信使
- 无钙RPMI（罗斯威尔公园纪念研究所）-1640培养基，结合囊性纤维化跨膜电导调节剂（CFTR）敲低，研究其对人表皮角质形成细胞系炎症、增殖和分化的影响
- 细胞迁移测定培养基
生化/生理作用
PD 98,059是一种类黄酮，同时是促分裂原活化蛋白激酶激酶（MAPKK）的特异性抑制剂。在小鼠体内，PD 98,059有助于阻断酵母聚糖刺激的器官功能障碍综合征和非败血性休克。目前确知它可抑制体外肥大。PD 98,059还诱导间充质基质细胞中的软骨形成。
法律信息
经Warner Lambert公司许可出售。
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)
Epidermal CFTR suppresses MAPK/NF-kappaB to promote cutaneous wound healing
Chen J
Cellular Physiology and Biochemistry, 39(6), 2262-2274 (2016)
Extracellular Matrix Proteins: Advances in Research and Application (2012)
Ki-Sun Park et al.
Nucleic acids research, 45(22), 12766-12779 (2017-12-16)
Imprinted genes occur in discrete clusters that are coordinately regulated by shared DNA elements called Imprinting Control Regions. H19 and Igf2 are linked imprinted genes that play critical roles in development. Loss of imprinting (LOI) at the IGF2/H19 locus on
D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression
Zeng C, et al.
Journal of Hypertension, 27(5), 1033-1033 (2009)
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