P215
PD 98,059
MAPKK inhibitor, solid
别名:
2-（2-氨基-3-甲氧基苯基）-4H-1-苯并吡喃-4-酮, PD98059
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关于此项目
经验公式（希尔记法）:
C16H13NO3
化学文摘社编号:
分子量:
267.28
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
产品名称
PD 98,059, solid
form
solid
Quality Level
color
yellow
solubility
DMSO: 10 mg/mL, clear
storage temp.
−20°C
SMILES string
COc1cccc(c1N)C2=CC(=O)c3ccccc3O2
InChI
1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChI key
QFWCYNPOPKQOKV-UHFFFAOYSA-N
Gene Information
Application
PD 98,059已用于：
- 生长培养基,作为有丝分裂原活化蛋白（MAP）激酶抑制剂，以研究与D1样受体作用有关的次级信使
- 无钙RPMI（罗斯威尔公园纪念研究所）-1640培养基，结合囊性纤维化跨膜电导调节剂（CFTR）敲低，研究其对人表皮角质形成细胞系炎症、增殖和分化的影响
- 细胞迁移测定培养基
Biochem/physiol Actions
PD 98,059是一种类黄酮，同时是促分裂原活化蛋白激酶激酶（MAPKK）的特异性抑制剂。在小鼠体内，PD 98,059有助于阻断酵母聚糖刺激的器官功能障碍综合征和非败血性休克。目前确知它可抑制体外肥大。PD 98,059还诱导间充质基质细胞中的软骨形成。
Legal Information
经Warner Lambert公司许可出售。
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存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Sepsis: Advances in Research and Treatment: 2011 Edition, 38-38 (2012)
D T Dudley et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(17), 7686-7689 (1995-08-15)
Treatment of cells with a variety of growth factors triggers a phosphorylation cascade that leads to activation of mitogen-activated protein kinases (MAPKs, also called extracellular signal-regulated kinases, or ERKs). We have identified a synthetic inhibitor of the MAPK pathway. PD
PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression
Maugeri G, et al.
Frontiers in Pharmacology, 7, 139-139 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P215-1MG | 04061834362616 |
| P215-5MG | 04061834362623 |