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质量水平
检测方案
≥98% (HPLC)
颜色
yellow
溶解性
DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow
H2O: insoluble
储存温度
2-8°C
SMILES字符串
O=C1c2ccccc2-c3n[nH]c4cccc1c34
InChI
1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChI key
ACPOUJIDANTYHO-UHFFFAOYSA-N
基因信息
human ... JUN(3725) , MAPK10(5602) , MAPK9(5601)
应用
C2C12肌原细胞经过SP600125处理后，被用来测试肌生成激细胞活。11它用于处理HepG2处理，测试在氧化胆固醇诱导坏死效果。12
生化/生理作用
SP600125是一种JNK的吡唑蒽酮抑制剂，和ATP竞争性抑制c-Jun的磷酸化。它能够避免炎症基因比如， COX-2, IL-2 IFN-γ和TNF-α.8,9活化。在脑缺血后它能够避免JNK激活，对缺血性中风有治疗作用。10
是c-Jun N端激酶（JNK）新型和选择抑制剂
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Increasingly, anti-cancer medications are being reported to induce cell death mechanisms other than apoptosis. Activating alternate death mechanisms introduces the potential to kill cells that have defects in their apoptotic machinery, as is commonly observed in cancer cells, including in
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Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
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