S5567
SP600125
≥98% (HPLC), powder or solid, JNK inhibitor
别名:
1,9-吡唑蒽酮, 吡唑并蒽酮
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关于此项目
经验公式（希尔记法）:
C14H8N2O
化学文摘社编号:
分子量:
220.23
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-955-6
MDL number:
Assay:
≥98% (HPLC)
Quality level:
产品名称
SP600125, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
color
yellow
solubility
DMSO: 20 mg/ml, clear to very slightly hazy, faintly yellow to yellow, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C1c2ccccc2-c3n[nH]c4cccc1c34
InChI
1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
InChI key
ACPOUJIDANTYHO-UHFFFAOYSA-N
Gene Information
human ... JUN(3725), MAPK10(5602), MAPK9(5601)
Application
C2C12肌原细胞经过SP600125处理后，被用来测试肌生成激细胞活。11它用于处理HepG2处理，测试在氧化胆固醇诱导坏死效果。12
Biochem/physiol Actions
SP600125是一种JNK的吡唑蒽酮抑制剂，和ATP竞争性抑制c-Jun的磷酸化。它能够避免炎症基因比如， COX-2, IL-2 IFN-γ和TNF-α.8,9活化。在脑缺血后它能够避免JNK激活，对缺血性中风有治疗作用。10
是c-Jun N端激酶（JNK）新型和选择抑制剂
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
商品
Naive pluripotent stem cells cultured in vitro using specialized media and inhibitors mimic "ground-state" cells from blastocysts.
Adrian Vallejo et al.
Nature communications, 8, 14294-14294 (2017-02-22)
KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report
Chenglu Peng et al.
Journal of agricultural and food chemistry, 67(32), 9009-9021 (2019-07-19)
Soybean allergy is a serious health risk to humans and animals; β-conglycinin is the primary antigenic protein in soybean. Intestinal porcine epithelial (IPEC-J2) cells were used as an in vitro physiological model of the intestinal epithelium to study the effects
Cheng Yin et al.
Cell transplantation, 28(6), 691-703 (2018-10-24)
Following central nervous system injury in mammals, failed axonal regeneration is closely related to dysneuria. Previous studies have shown that the obvious effects of apolipoprotein E (ApoE) on traumatic brain injury (TBI) were associated with an axonal mechanism. However, little
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| S5567-10MG | 04061836954574 |
| S5567-50MG | 04061836954581 |