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质量水平
检测方案
≥98% (HPLC)
形式
solid
颜色
white to off-white
溶解性
DMSO: ≥20 mg/mL
储存温度
−20°C
SMILES字符串
CS(=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI
1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25)
InChI key
CDMGBJANTYXAIV-UHFFFAOYSA-N
基因信息
human ... CYP1A2(1544) , CYP2C19(1557) , CYP2C9(1559) , CYP2D6(1565) , CYP3A4(1576) , IL1B(3553) , MAPK14(1432) , MAPK8IP2(23542) , RAF1(5894) , TNF(7124)
应用
使用SB 203580处理MDCK细胞以研究MAPK信号转导在诱导细胞膜的高渗性和钾耗竭中的作用。16 它被用于抑制小鼠皮层神经元17和人肝细胞癌细胞系中的MAPK信号转导。18
生化/生理作用
SB 203580是一种吡啶基咪唑，可抑制MAPKAP激酶-2的活化，以及在体内抑制热休克蛋白（HSP）27对IL-1、细胞应激和细菌内毒素的反应磷酸化。它不可抑制JNK或p42 MAP激酶，因此可用于研究p38 MAPK和MAPKAP激酶-2的生理作用和靶点。已有研究显示它可诱导丝氨酸/苏氨酸激酶Raf-1的活化，并且据报道其可抑制细胞因子的产生。
特点和优势
该化合物是激酶磷酸酶生物学研究的推荐产品。点击此处，了解更多精选激酶磷酸酶生物学产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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