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description
Dox-NP® (Liposomal Encapsulated Doxorubicin)
frozen liposomal suspension (buffer - 10% w/w sucrose, 10 mM histidine ~pH 6.5)
Assay
>99% (HPLC/MS)
form
dispersion
packaging
pkg of 1 × 5 mL (300115S-1EA)
manufacturer/tradename
Avanti Polar Lipids
application(s)
advanced drug delivery
shipped in
dry ice
storage temp.
−20°C
General description
Formulation: A Pegylated, long-circulating liposomal formulation with doxorubicin entrapped within an ammonium sulfate core via remote-loading. All unencapsulated was removed to yield a completely liposomal doxorubicin product. Liposomes are stored frozen for a longer shelf life.
Application
Dox-NP™(5mL vial) has been used as a sample to study its characteristics by asymmetrical-flow field flow fractionation (MD-AF4). It may also be used as an intravenous (i.v.) injection in flank or orthotopic animal models of cancer.
Packaging
10 mL amber serum vial (300115S-1EA)
Legal Information
Avanti is a registered trademark of Avanti Polar Lipids, Inc.
Dox-NP is a trademark of Avanti Polar Lipids, Inc.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
Physical characterization of liposomal drug formulations using multi-detector asymmetrical-flow field flow fractionation
Parot J, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society (2020)
J Parot et al.
Journal of controlled release : official journal of the Controlled Release Society, 320, 495-510 (2020-02-01)
Liposomal formulations for the treatment of cancer and other diseases are the most common form of nanotechnology enabled pharmaceuticals (NEPs) submitted for market approval and in clinical application today. The accurate characterization of their physical-chemical properties is a key requirement;
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