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Merck
CN

Q0750

Quinidine hydrochloride monohydrate

technical grade

Synonym(s):

6′-Methoxycinchonan-9-ol hydrochloride monohydrate

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About This Item

Empirical Formula (Hill Notation):
C20H24N2O2 · HCl · H2O
CAS Number:
6151-40-2
Molecular Weight:
378.89
NACRES:
NA.22
PubChem Substance ID:
57654579
UNSPSC Code:
12352100
EC Number:
205-001-1
MDL number:
MFCD00198101

Key Documents

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Product Name

Quinidine hydrochloride monohydrate, technical grade

InChI key

SGVZDMWHXVXUBY-KAIFKDDSSA-N

InChI

1S/C20H24N2O2.ClH.H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;1H2/t13-,14-,19+,20-;;/m0../s1

SMILES string

O.Cl.[H][C@@]1(C[C@@H]2CC[N@H]1C[C@@H]2C=C)[C@@H](O)c3ccnc4ccc(OC)cc34

grade

technical grade

impurities

≤20% Dihydroquinidine (according to USP specifications., actual content given on label)

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Related Categories

Application

Studied for pharmacological activity causing energy shifts from mitochondrial respiration to glycolysis

Biochem/physiol Actions

Class IA antiarrhythmic; potassium channel blocker.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000470020
0000469995
0000469995
0000470020
0000436291

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Miki Fukao et al.
European journal of drug metabolism and pharmacokinetics, 41(6), 819-824 (2015-12-03)
We have recently found an H We investigated the uptake and efflux of quinidine in MDCK cells. The uptake of 100 µM quinidine into MDCK cells was decreased by acidification of extracellular pH or alkalization of intracellular pH. In addition, the
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