900863
2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol
≥95%
Synonym(s):
3-(3-Butyn-1-yl)-3H-diazirine-3-ethanol, Hydroxyl diazirine alkyne, Probe building block
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About This Item
Empirical Formula (Hill Notation):
C7H10N2O
CAS Number:
Molecular Weight:
138.17
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.22
Application
2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Other Notes
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Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling
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Product No.
Description
Pricing
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Articles
In partnership with Pfizer chemists, we have compiled a collection of trifunctional building blocks to enable development of probes.
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