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805092

Sigma-Aldrich

PLGA nanoparticles

100 nm average diameter

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Synonym(s):
Degradex® PLGA, poly(D,L-lactide-co-glycolide)
Linear Formula:
HO(C3H4O2)x(C2H2O2)yH
UNSPSC Code:
12162002
NACRES:
NA.23

form

powder

Quality Level

100

average diameter

100 nm

density

1.3 g/cm3

shipped in

wet ice

storage temp.

−20°C

Related Categories

General description

Degradex® is made with poly(D,L-lactide-co-glycolide) with an L/G ratio of 50/50 and a Mw of 30,000.
To re-constitute:
  • Remove the product from freezer.
  • Wait until temperature rises to the ambient temperature.
  • Add DI water or buffer to the container.
  • Vortex and sonicate for 5 minutes to ensure the microspheres are well suspended.
The particle size of the PLGA nanoparticles are closely dependent on both the nature and concentration of the stabilizer and polymer.

Application

Plain PLGA particles can be used for testing system compatibility in drug delivery research. Particles can be used as carriers by attaching drug or biological/chemical entities to particle surface. PLGA particles are used for controlled release, sustained release and targeted drug delivery.A study reports the use of PLGA nanoparticles as estrogen carriers. The carrier-drug system was prepared by emulsification-diffusion method.

Legal Information

Degradex is a registered trademark of Phosphorex, Inc.

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WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method
Kwon HY, et al.
Colloids and Surfaces. A, Physicochemical and Engineering Aspects, 182(1-3), 123-130 (2001)
The Characteristics and Mechanisms of Uptake of PLGA Nanoparticles in Rabbit Conjunctival Epithelial Cell Layers
Qaddoumi MG, et al.
Pharmaceut. Res., 21(4), 641-648 null

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