918881
NanoFabTx™ PEG-PCL drug formulation screening kit
for synthesis of PEGylated nanoparticles
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Synonym(s):
Drug delivery reagent kit, NanoFabTx reagent kit, Nanoparticle synthesis kit, PEG-PCL
UNSPSC Code:
12161503
NACRES:
NA.23
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description
Drug loading screening kit, for synthesis of PEGylated PCL nanoparticles
Kit components :
PEGPCL-L(915203-500mg)
PEGPCL-H(912549-500mg)
PEGPCL-UH (917788-500mg)
Stabilizer-Nano (907766-5g)
Quality Level
application(s)
advanced drug delivery
storage temp.
2-8°C
Related Categories
General description
NanoFabTx™ PEG-PCL drug loading screening kit is a ready-to-use nanoformulation kit for the synthesis of PEGylated PCL nanoparticles 50 to 130 nm in size. This kit provides properly selected PEGylated PCL polymers, stabilizer, and protocols for the synthesis of drug-encapsulating nanoparticles by nanoprecipitation and microfluidic methods. Three different PEGylated PCLs are included in this kit, allowing rapid screening of optimal materials for enhancing drug loading. Protocols for two different particle synthesis methods are included.
- A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
- A Microfluidics protocol using commercial platforms or syringe pumps.
Application
NanoFabTx™ nanoformulation reagent kits enable users to encapsulate a wide variety of therapeutic drug molecules for targeted or extended drug delivery without the need for lengthy trial-and-error optimization. Drug encapsulated particles synthesized with the NanoFabTx™ kits are suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery. Poly (ethylene glycol)-block-poly(caprolactone) (PEG-PCL) is a biocompatible and biodegradable polymer that has been approved by the FDA and the EMA for biomedical and pharmaceutical applications. PEG-PCL based nanoparticles have been widely used as drug delivery systems for different types of therapeutic molecules, to achieve controlled drug release. PEG-PCL nanoparticles offer a slow degradation rate, ideal for long-term implantation and sustained release. And unlike other polymer materials, PEG-PCL does not produce acidic byproducts upon degradation.
Features and Benefits
- Ready-to-use nanoformulation kit for PEGylated PCL nanoparticles
- Choose from either nanoprecipitation or microfluidics-based protocols
- Create specifically sized, biodegradable, PEGylated PCL nanoparticles
- Maximize the encapsulation of hydrophobic drugs
- Three different PEGylated PCLs are included
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
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MPEG−PCL copolymeric nanoparticles in drug delivery systems.
Hossein D, et al.
Cogent medicine., 3(1) (2016)
MaLing Gou et al.
Current drug targets, 12(8), 1131-1150 (2011-03-30)
Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In
Yong Hu et al.
Journal of controlled release : official journal of the Controlled Release Society, 118(1), 7-17 (2007-01-24)
Core-shell nanoparticles were prepared from di-block copolymer of methoxy poly(ethylene glycol)-polycaprolactone (MePEG-PCL) and tri-block copolymer of polycaprolactone-poly(ethylene glycol)-polycaprolactone (PCL-PEG-PCL). The MePEG-PCL copolymers form nanoparticles with PEG "brush" on their surfaces and PCL-PEG-PCL copolymers form nanoparticles with a "mushroom-like" structure on
Functionalized Solid-Sphere PEG-b-PCL Nanoparticles to Target Brain Capillary Endothelial Cells In Vitro.
Grossen P, et al.
Journal of Nanomaterials (2016)
Philip Grossen et al.
Journal of controlled release : official journal of the Controlled Release Society, 260, 46-60 (2017-05-26)
The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at
Articles
NanoFabTx™ platform accelerates drug development with ready-to-use formulations and microfluidic devices for particle synthesis.
NanoFabTX kits enable precise drug delivery with lipid nanoparticles and liposomes for mRNA and nucleic acids.
Professor Robert K. Prud’homme introduces flash nanoprecipitation (FNP) for nanoparticle fabrication, which is a scalable, rapid mixing process for nanoparticle formulations.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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