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764213

Sigma-Aldrich

Biotin-PEG4-alkyne

for copper catalyzed click labeling

Synonym(s):

Polyethylene glycol, Acetylene-PEG4-biotin conjugate

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About This Item

Empirical Formula (Hill Notation):
C21H35N3O6S
CAS Number:
1262681-31-1
Molecular Weight:
457.58
MDL number:
MFCD32689639
UNSPSC Code:
12161502
PubChem Substance ID:
329767107
NACRES:
NA.22
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Quality Level

100

Assay

95%

form

solid

reaction suitability

reaction type: click chemistry

mp

55-64 °C

storage temp.

−20°C

SMILES string

O=C(NCCOCCOCCOCCOCC#C)CCCC[C@@H](SC1)[C@@]2([H])[C@]1([H])NC(N2)=O

InChI

1S/C21H35N3O6S/c1-2-8-27-10-12-29-14-15-30-13-11-28-9-7-22-19(25)6-4-3-5-18-20-17(16-31-18)23-21(26)24-20/h1,17-18,20H,3-16H2,(H,22,25)(H2,23,24,26)/t17-,18-,20-/m1/s1

InChI key

SKMJWNZZFUDLKQ-QWFCFKBJSA-N

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This Item
FD2000SFD40SFD250S
Sigma-Aldrich

52471

Fluorescein isothiocyanate–dextran

Fluorescein isothiocyanate–dextran average mol wt 2,000,000

FD2000S

Fluorescein isothiocyanate–dextran

Fluorescein isothiocyanate–dextran average mol wt 40,000

FD40S

Fluorescein isothiocyanate–dextran

Fluorescein isothiocyanate–dextran average mol wt 250,000

FD250S

Fluorescein isothiocyanate–dextran

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

powder or crystals

form

powder

form

powder

form

powder

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

mol wt

average mol wt 2,000,000

mol wt

average mol wt 2,000,000

mol wt

average mol wt 40,000

mol wt

average mol wt 250,000

extent of labeling

0.001-0.020 mol FITC per mol glucose (substitution)

extent of labeling

0.003-0.020 mol FITC per mol glucose

extent of labeling

0.003-0.020 mol FITC per mol glucose

extent of labeling

0.003-0.020 mol FITC per mol glucose

Application

Biotin-PEG4-alkyne may be used for the modification of 4-azidophenylalanine (AzPhe) silk fibroin via bioorthogonal azide–alkyne cycloaddition reaction for developing photopatternable protein material.[1]
Biotinylation reagent for labeling azide containing molecules or biomolecules using copper-catalyzed 1,3 dipolar cycloaddition click chemistry. The alkyne group reacts with azides to form a stable triazole linkage, facilitating the introduction of biotin into your azide modified system of interest.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Chemoproteomic Profiling of Gut Microbiota-Associated Bile Salt Hydrolase Activity

Fluorescent Heterotelechelic Single-Chain Polymer Nanoparticles: Synthesis, Spectroscopy, and Cellular Imaging

Arginine-Selective Chemical Labeling Approach for Identification and Enrichment of Reactive Arginine Residues in Proteins

Selective Imaging of Gram-Negative and Gram-Positive Microbiotas in the Mouse Gut

Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction

A Modular Probe Strategy for Drug Localization, Target Identification and Target Occupancy Measurement on Single Cell Level

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCV5242
    MKCT5189
    MKCQ4869
    MKCP8431
    MKCN7955

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    Maheshika S K Wanigasekara et al.
    ACS omega, 3(10), 14229-14235 (2019-08-29)
    Modification of arginine residues using dicarbonyl compounds is a common method to identify functional or reactive arginine residues in proteins. Arginine undergoes several kinds of posttranslational modifications in these functional residues. Identifying these reactive residues confidently in a protein or
    Lili Lu et al.
    Angewandte Chemie (International ed. in English), 54(33), 9679-9682 (2015-06-24)
    Glycosylphosphatidylinositol (GPI) anchoring of proteins to the cell surface is important for various biological processes, but GPI-anchored proteins are difficult to study. An effective strategy was developed for the metabolic engineering of cell-surface GPIs and GPI-anchored proteins by using inositol
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    Current Biology, 26(18), R834-R835 (2016)
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