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Key Documents

52471

Sigma-Aldrich

Fluorescein isothiocyanate–dextran

average mol wt 2,000,000

Synonym(s):

FITC–Dextran 2000, FITC–Dextran

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About This Item

CAS Number:
60842-46-8
MDL number:
MFCD00131092
UNSPSC Code:
12352201
NACRES:
NA.32
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biological source

synthetic

Quality Level

100

conjugate

FITC conjugate

form

powder or crystals

mol wt

average mol wt 2,000,000

extent of labeling

0.001-0.020 mol FITC per mol glucose (substitution)

fluorescence

λex 493 nm; λem 520 nm in 0.1 M Tris pH 8.0

application(s)

cell analysis

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1 of 4

This Item
FD2000SFD40SFD250S
Sigma-Aldrich

52471

Fluorescein isothiocyanate–dextran

Fluorescein isothiocyanate–dextran average mol wt 2,000,000

FD2000S

Fluorescein isothiocyanate–dextran

Fluorescein isothiocyanate–dextran average mol wt 40,000

FD40S

Fluorescein isothiocyanate–dextran

Fluorescein isothiocyanate–dextran average mol wt 250,000

FD250S

Fluorescein isothiocyanate–dextran

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

bacterial (Leuconostoc mesenteroides)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

powder or crystals

form

powder

form

powder

form

powder

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

conjugate

FITC conjugate

mol wt

average mol wt 2,000,000

mol wt

average mol wt 2,000,000

mol wt

average mol wt 40,000

mol wt

average mol wt 250,000

extent of labeling

0.001-0.020 mol FITC per mol glucose (substitution)

extent of labeling

0.003-0.020 mol FITC per mol glucose

extent of labeling

0.003-0.020 mol FITC per mol glucose

extent of labeling

0.003-0.020 mol FITC per mol glucose

Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC–Dextran 2000) is use as a fluorescent probe to study the permeability of structures such as intercellular junctions involved in processes such as hearing and vascular permeability and the integrity of the blood brain barrier (BBB).

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCM8297
    BCCK7364
    BCCG5113
    BCCD8600
    BCCC2553

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    Sung Ji Ahn et al.
    Biomedical optics express, 11(5), 2665-2678 (2020-06-06)
    We show that third harmonic generation (THG) microscopy using a 1-MHz train of 1,300-nm femtosecond duration laser pulses enabled visualization of the structure and quantification of flow speed in the cortical microvascular network of mice to a depth of >
    Guiliang Zheng et al.
    BMC neuroscience, 13, 71-71 (2012-06-21)
    Exposure to intense noise causes the excessive movement of the organ of Corti, stretching the organ and compromising sensory cell functions. We recently revealed changes in the transcriptional expression of multiple adhesion-related genes during the acute phases of cochlear damage
    Elodie Debefve et al.
    Lasers in surgery and medicine, 43(7), 696-704 (2011-11-08)
    Photodynamic therapy (PDT) affects vascular barrier function and thus increases vessel permeability. This phenomenon may be exploited to facilitate targeted drug delivery and may lead to a new clinical application of photodynamic therapy. Here, we investigate the role of leukocyte
    Sangmi Ock et al.
    Biochemical and biophysical research communications, 516(2), 350-356 (2019-06-19)
    Receptor activator of NF-κB ligand (RANKL) is a member of the TNF superfamily. RANKL increases endothelial permeability and induces angiogenesis, suggesting its critical roles in the vasculature. Despite the evidence implicating RANKL in vascular pathology, its role in ischemic retinopathy
    Mercy Afadzi et al.
    IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 60(1), 21-33 (2013-01-05)
    The mechanism involved in the ultrasoundenhanced intracellular delivery of fluorescein-isothiocyanate (FITC)-dextran (molecular weight 4 to 2000 kDa) and liposomes containing doxorubicin (Dox) was studied using HeLa cells and an ultrasound transducer at 300 kHz, varying the acoustic power. The cellular
    View All Related Papers

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