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719897

Sigma-Aldrich

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)

acid terminated, viscosity 0.16-0.24 dL/g 

Synonym(s):

PLGA

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1 G
CN¥1,300.27
5 G
CN¥4,179.97

CN¥1,300.27

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1 G
CN¥1,300.27
5 G
CN¥4,179.97

About This Item

Linear Formula:
[C3H4O2]x[C2H2O2]y
CAS Number:
26780-50-7
MDL number:
MFCD00131930
UNSPSC Code:
12162002
NACRES:
NA.23

CN¥1,300.27

Available to ship onApril 01, 2025Details

Request a Bulk Order

form

amorphous

feed ratio

lactide:glycolide 50:50

degradation timeframe

<3 months

viscosity

0.16-0.24 dL/g

transition temp

Tg 42-46 °C

storage temp.

2-8°C

SMILES string

O2C(C(=O)OC(C2=O)C)C.O1CC(=O)OCC1=O

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

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This Item
719900739944739952
Resomer&#174; RG 502 H, Poly(D,L-lactide-co-glycolide) acid terminated, viscosity 0.16-0.24&#160;dL/g&#160;

719897

Resomer® RG 502 H, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 504 H, Poly(D,L-lactide-co-glycolide) acid terminated, lactide:glycolide 50:50, Mw 38,000-54,000

719900

Resomer® RG 504 H, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 504, Poly(D,L-lactide-co-glycolide) lactide:glycolide 50:50, ester terminated, Mw 38,000-54,000

739944

Resomer® RG 504, Poly(D,L-lactide-co-glycolide)

Resomer&#174; RG 503, Poly(D,L-lactide-co-glycolide) lactide:glycolide 50:50, ester terminated, Mw 24,000-38,000

739952

Resomer® RG 503, Poly(D,L-lactide-co-glycolide)

viscosity

0.16-0.24 dL/g

viscosity

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

viscosity

0.45-0.60 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

viscosity

0.32-0.44 dL/g, 0.1 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)

form

amorphous

form

amorphous

form

amorphous

form

amorphous

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

feed ratio

lactide:glycolide 50:50

degradation timeframe

<3 months

degradation timeframe

<3 months

degradation timeframe

<3 months

degradation timeframe

<3 months

Application

Poly(D,L-lactide-co-glycolide) (PLGA) canbe used:

  • In the formulation ofa non-aqueous drug delivery system for H2S donors to aid thesustained release of the drug.
  • To prepare a polymer blend containing Ganciclovir-loaded microspheresdispersed in PLGA–PEG–PLGA polymer gel. This formulation can be used as asustained delivery system for Ganciclovir drug.
It can also be used to fabricate NO-releasingglucose and lactate sensors.

Legal Information

Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    MKCX2944
    MKCX2102
    MKCV8978
    BCCH1660
    BCCG6651

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    A Patil et al.
    AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)
    Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.
    Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.
    Cai W,et al.
    Biomaterials, 33(32), 7933-7944 (2012)
    Sridhar Duvvuri et al.
    Journal of controlled release : official journal of the Controlled Release Society, 108(2-3), 282-293 (2005-10-19)
    The purpose of this work is to develop empirical equations for describing the in vitro ganciclovir (GCV) release from PLGA microspheres and also to develop and characterize a formulation containing GCV loaded PLGA microspheres dispersed in thermogelling PLGA-PEG-PLGA polymer gel.
    Qinyi Yan et al.
    Biosensors & bioelectronics, 26(11), 4276-4282 (2011-05-20)
    Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or
    Z Zhuang et al.
    Journal of dental research, 98(2), 200-208 (2018-11-06)
    Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio
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