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Resomer^® RG 502 H, Poly(D,L-lactide-co-glycolide)

Name: Resomer<SUP>®</SUP> RG 502 H, Poly(<SC>D,L</SC>-lactide-<I>co</I>-glycolide)
Brand: ALDRICH

acid terminated, viscosity 0.16-0.24 dL/g

Synonym(s):

PLGA

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About This Item

Linear Formula:

[C₃H₄O₂]_x[C₂H₂O₂]_y

CAS Number:

26780-50-7

UNSPSC Code:

12162002

NACRES:

NA.23

Quality Level

200

form

amorphous

feed ratio

lactide:glycolide 50:50

degradation timeframe

<3 months

viscosity

0.16-0.24 dL/g

transition temp

T_g 42-46 °C

storage temp.

2-8°C

InChI

1S/C6H8O4.C4H4O4/c1-3-5(7)10-4(2)6(8)9-3;5-3-1-7-4(6)2-8-3/h3-4H,1-2H3;1-2H2

InChI key

LCSKNASZPVZHEG-UHFFFAOYSA-N

Related Categories

Biomedical Polymers

Application

Poly(D,L-lactide-co-glycolide) (PLGA) canbe used:

In the formulation ofa non-aqueous drug delivery system for H₂S donors to aid thesustained release of the drug.
To prepare a polymer blend containing Ganciclovir-loaded microspheresdispersed in PLGA–PEG–PLGA polymer gel. This formulation can be used as asustained delivery system for Ganciclovir drug.

It can also be used to fabricate NO-releasingglucose and lactate sensors.

Legal Information

Product of Evonik

RESOMER is a registered trademark of Evonik Rohm GmbH

related product

Product No.

Description

Pricing

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Sustained-Release Delivery System of a Slow Hydrogen Sulfide Donor, GYY 4137, for Potential Application in Glaucoma.

A Patil et al.

AAPS PharmSciTech, 18(6), 2291-2302 (2017-01-20)

Hydrogen sulfide (H2S) targets both underlying factors in glaucoma pathogenesis by reducing elevated intraocular pressure (IOP) and providing retinal neuroprotection, whereas the current clinical approaches targets only reducing IOP. Therefore, H2S could be a potential superior candidate for glaucoma pharmacotherapy.

Induction of M2 Macrophages Prevents Bone Loss in Murine Periodontitis Models.

Z Zhuang et al.

Journal of dental research, 98(2), 200-208 (2018-11-06)

Periodontitis is characterized by the progressive destruction of tooth-supporting alveolar bone, which is mainly caused by chronic inflammation in response to persistent bacterial insult. It has recently become clear that the pathogenesis of periodontitis is associated with a high ratio

Intravascular glucose/lactate sensors prepared with nitric oxide releasing poly(lactide-co-glycolide)-based coatings for enhanced biocompatibility.

Qinyi Yan et al.

Biosensors & bioelectronics, 26(11), 4276-4282 (2011-05-20)

Intravenous amperometric needle-type enzymatic glucose/lactate sensors intended for continuous monitoring are prepared with a novel nitric oxide (NO) releasing layer to improve device hemocompatibility. To create an underlying NO release coating, the sensors with immobilized enzymes (either glucose oxidase or

Development of a novel formulation containing poly(d,l-lactide-co-glycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir.

Sridhar Duvvuri et al.

Journal of controlled release : official journal of the Controlled Release Society, 108(2-3), 282-293 (2005-10-19)

The purpose of this work is to develop empirical equations for describing the in vitro ganciclovir (GCV) release from PLGA microspheres and also to develop and characterize a formulation containing GCV loaded PLGA microspheres dispersed in thermogelling PLGA-PEG-PLGA polymer gel.

Diazeniumdiolate-doped poly (lactic-co-glycolic acid)-based nitric oxide releasing films as antibiofilm coatings.

Cai W,et al.

Biomaterials, 33(32), 7933-7944 (2012)

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