AKT1
v-akt murine thymoma viral oncogene homolog 1
别名:
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
物种:
Human AKT1 (207), Mouse Akt1 (11651), Rat Akt1 (24185), cow AKT1 (280991), fruit fly Akt1 (41957), chicken AKT1 (395928), Zebrafish akt1 (101910198), Goat AKT1 (100860904), sheep AKT1 (100294652), dog AKT1 (490878) ...展开
UniProtKB ID:
基因ID:
- Human(207) Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
- Mouse(11651) thymoma viral proto-oncogene 1
- Rat(24185) v-akt murine thymoma viral oncogene homolog 1
- cow(280991) v-akt murine thymoma viral oncogene homolog 1
- fruit fly(41957) CG4006 gene product from transcript CG4006-RA
- chicken(395928) v-akt murine thymoma viral oncogene homolog 1
- Zebrafish(101910198) v-akt murine thymoma viral oncogene homolog 1
- Goat(100860904) v-akt murine thymoma viral oncogene homolog 1
- sheep(100294652) v-akt murine thymoma viral oncogene homolog 1
- dog(490878) v-akt murine thymoma viral oncogene homolog 1
- domestic guinea pig(100714724) v-akt murine thymoma viral oncogene homolog 1
- sheep(101104184) v-akt murine thymoma viral oncogene homolog 1
- domestic cat(101087931) v-akt murine thymoma viral oncogene homolog 1
- naked mole-rat(101700695) v-akt murine thymoma viral oncogene homolog 1
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ELISA
Antibodies
货号
说明
物种反应性
应用
Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Alexa Fluor™ 488, clone SKB1, Upstate®, from mouse,
物种反应性
human, mouse, rat
应用
flow cytometry
immunocytochemistry
immunofluorescence
western blot
immunocytochemistry
immunofluorescence
western blot
Anti-phospho-AKT1 (pThr308) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗Akt / PKB抗体，PH结构域，克隆SKB1, clone SKB1, Upstate®, from mouse,
物种反应性
human, mouse, rat
应用
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunoprecipitation (IP)
western blot
Monoclonal Anti-AKT1 antibody produced in mouse, clone 2E11, purified immunoglobulin, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
Cell Lines
货号
说明
物种
Small Molecule - Inhibitor
Proteins
货号
说明
物种
Akt1/PKBα Protein, active, 15 µg, Active, recombinant full-length human Akt1, containing N-terminal His6 tag, for use in IP-Kinase Assays & Kinase Assays.,
物种
human
Akt1 active human, recombinant, expressed in baculovirus infected Sf9 cells, ≥75% (SDS-PAGE),
物种
human
AKT1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
SILu™Prot AKT1,RAC-alpha serine/threonine-protein kinase human, recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C- and 15N-labeled,
物种
human