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G6776

Sigma-Aldrich

染料木黄酮

from Glycine max (soybean), ~98% (HPLC)

别名:

4′,5,7-三羟基异黄酮, 5,7-二羟基-3-（4-羟基苯基）-4H-1-苯并吡喃-4-酮

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About This Item

经验公式（希尔记法）:
C15H10O5
CAS号:
446-72-0
分子量:
270.24
Beilstein:
263823
EC 号:
207-174-9
MDL编号:
MFCD00016952
UNSPSC代码:
12352200
PubChem化学物质编号:
24895273
NACRES:
NA.77

生物来源

Glycine max (soybean)

质量水平

200

方案

~98% (HPLC)

表单

powder

mp

>280 °C

溶解性

DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O

InChI

1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-13-6-10(17)5-12(18)14(13)15(11)19/h1-7,16-18H

InChI key

TZBJGXHYKVUXJN-UHFFFAOYSA-N

基因信息

human ... AKT1(207) , CYP19A1(1588) , EGFR(1956) , ESR1(2099) , ESR2(2100)
mouse ... Esr1(13982) , Hexa(15211)
rat ... Adora1(29290) , Adora2a(25369) , Ar(24208)

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一般描述

金雀异黄素是来自大豆的异黄酮营养保健品，同时也是一种植物雌激素。它来源于染料木苷。

应用

金雀异黄素已被用作：
  • 作为抗癌剂用于测试其在宫颈腺癌细胞中的细胞毒性
  • 作为多酚用于测试其对精子线粒体中活性氧的作用
  • 测试其对紫外照射下皮肤和瘢痕疙瘩成纤维细胞的自由基清除作用

生化/生理作用

金雀异黄素具有抗氧化功能，并可有效淬灭活性氧。它有益于人体健康。
酪氨酸蛋白激酶抑制剂; 在其他蛋白激酶反应中，ATP的竞争性抑制剂。 抗血管生成剂，可下调参与控制血管生成的基因的转录。

特点和优势

该化合物是《受体分类及信号转导手册》上Met页面上的特色化合物。想要浏览手册的其他页面， 请单击此处。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000368464
0000358582
0000327298
0000358582
0000368464

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