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Merck
CN

T3830

Sigma-Aldrich

曲西瑞宾 水合物

≥97% (HPLC)

别名:

API-2, Akt/PKB信号传导抑制剂2, NSC 154020, TCN, VD-0002, 抑制剂 V

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About This Item

经验公式(希尔记法):
C13H16N6O4 · xH2O
CAS号:
分子量:
320.30 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥97% (HPLC)

表单

powder

颜色

tan

溶解性

DMSO: >10 mg/mL

储存温度

2-8°C

SMILES字符串

O.Cn1nc(N)c2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c4ncnc1c24

InChI

1S/C13H16N6O4.H2O/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13;/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17);1H2/t6-,8-,9-,13-;/m1./s1

InChI key

SPGRLWCWHWRPHX-DOKXERMVSA-N

基因信息

human ... AKT1(207)
mouse ... AKT1(11651)
rat ... AKT1(24185)

应用

曲西立滨水合物已被用于研究二乙基二硫代氨基甲酸酯(DDC)对肝星状细胞中基质金属蛋白酶-1(MMP-1)的作用1。它还被用于分析过表达瑞典突变APP(SweAPP N2a细胞)的N2a细胞中(-)-表没食子儿茶素-3-没食子酸酯(EGCG)的ADAM 10激活作用2

生化/生理作用

曲西瑞宾是一种高度选择性的Akt/PKB抑制剂,可选择性抑制Akt1/2/3的细胞磷酸化/激活。

特点和优势

《受体分类和信号转导》手册的 PKB/Akt 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

制备说明

曲西立滨水合物溶于DMSO,溶解浓度大于10 mg/ml。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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