培养基过滤
上游生物负荷控制主要着眼于防止微生物进入细胞培养过程。常规进行无菌过滤可以保护生物反应器和上游过程免遭污染。
选择合适的过滤器进行细胞培养基过滤
我们可提供多种培养基过滤选项，保证每个步骤的无菌性和高性能。过滤器的选择需要以风险分析作为指导，从而识别所需的生物负荷控制水平、细胞培养基处理的效率（通量）以及可用的过滤器形式。在最终确定过滤器选择之前，应确认细胞培养过程的可接受性能标准。
Millipore Express® SHR（无菌、高保留率） 该过滤器包含一层0.1 µm的聚醚砜（PES）膜，并可选配一体式的0.5 µm PES膜预过滤器，以对高通量膜进行保护，防止过早发生堵塞。这些过滤器通常可去除≥7.0对数级的支原体并达到无菌级性能。
Millipore Express® SHC（无菌、大容量） 过滤器包含两层（0.5/0.2 µm）PES膜，可提供出色的通量和堵塞流的能力。这些过滤器具有无菌级的性能。
Durapore® 0.1 µm和0.22 µm 过滤器包含一层聚偏二氟乙烯（PVDF）膜，并可提供高流速和通量。这些过滤器具有无菌级的性能。
相关资源
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