推荐产品
Agency
Ph. Eur.
质量水平
产品线
EMPROVE® ESSENTIAL
形式
powder
应用
pharmaceutical
solid formulation
solubility enhancement
储存温度
15-25°C
InChI
1S/C2H4O/c1-2-3/h2-3H,1H2
InChI key
IMROMDMJAWUWLK-UHFFFAOYSA-N
一般描述
With a lower degree of hydrolysis along the PVA chain, Parteck® MXP 3-82 Polyvinyl alcohol is especially beneficial in forming strong interactions with hydrophobic drug molecules – in the solid state and in solution. Due to this, Parteck® MXP 3-82 excipient has very high capabilities as a precipitation inhibitor and can maintain high levels of supersaturation for physiologically relevant timescales. As a result, Parteck® MXP 3-82 Polyvinyl alcohol can provide solubility enhancement for even the most challenging molecules.
应用
Parteck® MXP 3-82 is a PVA-based excipient that is used in Hot Melt Extrusion for Solubility Enhancement in oral solid dosage forms.
特点和优势
- Superior supersaturation performance via precipitation inhibition
- High thermostability up to 250°C, extending the potential application range
- Stable high drug loads and suitability with a broad range of APIs
- Flexible release kinetics
- Compatible with several downstream processing capabilities, like direct compression, continuous manufacturing, thin film extrusion and 3D printing
- Optimized powder properties for excellent performance in the HME process
- Suitable polymer properties for HME, spray drying and 3D printing processes
法律信息
Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
No data available
闪点(°C)
No data available
法规信息
新产品
商品
3D printing can overcome challenges during formulation development, with a focus on enhancing API bioavailability in solid dispersions. Find out how in this technical article.
Our overview of API solubility and dissolution enhancement methods can help you decide between the many options to take during formulation.
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