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933589

Sigma-Aldrich

NanoFabTx™ NanoFlash PEG Lipid Mix

for CIJ synthesis of PEGylated liposomes

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25 G
CN¥852.84
100 G
CN¥861.16
500 G
CN¥3,092.76
1 KG
CN¥7,152.31
10 KG
CN¥33,034.01

CN¥852.84

预计发货时间April 07, 2025详情

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25 G
CN¥852.84
100 G
CN¥861.16
500 G
CN¥3,092.76
1 KG
CN¥7,152.31
10 KG
CN¥33,034.01

About This Item

UNSPSC代码:
12352211
NACRES:
NA.21

CN¥852.84

预计发货时间April 07, 2025详情

获取大包装报价

质量水平

100

储存温度

−20°C

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此商品
436143L450971725
十二烷基硫酸钠 BioReagent, suitable for electrophoresis, for molecular biology, ≥98.5% (GC)

L3771

十二烷基硫酸钠

十二烷基硫酸钠 ACS reagent, ≥99.0%

436143

十二烷基硫酸钠

十二烷基硫酸钠 ReagentPlus®, ≥98.5% (GC)

L4509

十二烷基硫酸钠

十二烷基硫酸钠 BioUltra, for molecular biology, ≥99.0% (GC)

71725

十二烷基硫酸钠

suitability

suitable for electrophoresis

suitability

-

suitability

-

suitability

suitable for electrophoresis

grade

for molecular biology

grade

ACS reagent

grade

-

grade

for molecular biology

form

powder

form

solid

form

powder

form

powder

technique(s)

electrophoresis: suitable

technique(s)

-

technique(s)

-

technique(s)

-

aggregation number

62

aggregation number

-

aggregation number

62

aggregation number

62

应用

NanoFabTx™ NanoFlash PEG Lipid Mix a ready-to-use nanoformulation lipid blend that includes lyophilized lipids and step-by-step instructions for synthesizing PEGylated liposomes for small molecule drug delivery applications. Lipid-based formulations are widely used for drug delivery and enable improved therapeutic efficacy of a range of drug types PEGylated liposomes are capable of encapsulating both hydrophilic and lipophilic compounds and are an effective mechanism to increase the efficiency of drug delivery by prolonging the lifetime of the drug-encapsulated liposome.
This lipid mix has been curated and designed for flash nanoprecipitiaton (FNP) synthesis using a confined impingement jet (CIJ) mixer, such as the NanoFabTx™ NanoFlash CIJ Mixer, and detailed step-by-step instructions are provided.

特点和优势

  • A ready-to-use nanoformulation lipid blend for the synthesis of PEGylated liposomes
  • Step-by-step protocols (extrusion and microfluidics) developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for stealth PEGylated liposomes for small molecule encapsulation
The NanoFabTx™- PEG Lipid Mix provides reagents and protocols for extrusion and microfluidics to synthesize liposomes for drug delivery research application. This reagent kit can be combined with the NanoFabTx™ Microfluidic - nano device kit (Cat.No. 91153) for microfluidic synthesis of PEGylated liposomes. Comprehensive protocols for liposome synthesis are included:

  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

法律信息

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

储存分类代码

11 - Combustible Solids

WGK

WGK 3

法规信息

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    Which polymers can make nanoparticulate drug carriers long-circulating?
    VP, Torchilin, et al.
    Advanced Drug Delivery Reviews, 16, 141?155-141?155 (1995)
    Jing Han et al.
    Journal of pharmaceutical sciences, 101(10), 4018-4023 (2012-07-11)
    Johnson and Prud'homme (2003. AICHE J 49:2264-2282) introduced the confined impingement jets (CIJ) mixer to prepare nanoparticles loaded with hydrophobic compounds (e.g., drugs, inks, fragrances, or pheromones) via flash nanoprecipitation (FNP). We have modified the original CIJ design to allow
    L D Mayer et al.
    Biochimica et biophysica acta, 1025(2), 143-151 (1990-06-27)
    Studies from this laboratory (Mayer et al. (1986) Biochim. Biophys. Acta 857, 123-126) have shown that doxorubicin can be accumulated into liposomal systems in response to transmembrane pH gradients (inside acidic). Here, detailed characterizations of the drug uptake and retention
    D Papahadjopoulos et al.
    Proceedings of the National Academy of Sciences of the United States of America, 88(24), 11460-11464 (1991-12-15)
    The results obtained in this study establish that liposome formulations incorporating a synthetic polyethylene glycol-derivatized phospholipid have a pronounced effect on liposome tissue distribution and can produce a large increase in the pharmacological efficacy of encapsulated antitumor drugs. This effect
    A L Klibanov et al.
    FEBS letters, 268(1), 235-237 (1990-07-30)
    Incorporation of dioleoyl N-(monomethoxy polyethyleneglycol succinyl)phosphatidylethanolamine (PEG-PE) into large unilamellar liposomes composed of egg phosphatidylcholine:cholesterol (1:1) does not significantly increase the content leakage when the liposomes are exposed to 90% human serum at 37 degrees C, yet the liposomes show
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