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Merck
CN

SCN11A

sodium channel, voltage-gated, type XI, alpha subunit

别名:
NAV1.9, NaN, SCN12A, SNS-2
物种:
Human SCN11A (11280), Mouse Scn11a (24046), Rat Scn11a (29701), domestic guinea pig Scn11a (100734219), Domestic Rabbit SCN11A (100349709), sheep SCN11A (101117022), cow SCN11A (535956), domestic cat SCN11A (101085312), dog SCN11A (485593), naked mole-rat Scn11a (101723747)
UniProtKB ID:
Q9UI33, A6NN05, C9JD48, C9JR31, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0
基因ID:
  • Human(11280) Summary: Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]
  • Mouse(24046) sodium channel, voltage-gated, type XI, alpha
  • Rat(29701) sodium channel, voltage-gated, type XI, alpha subunit
  • domestic guinea pig(100734219) sodium channel, voltage-gated, type XI, alpha subunit
  • Domestic Rabbit(100349709) sodium channel, voltage-gated, type XI, alpha subunit
  • sheep(101117022) sodium channel, voltage-gated, type XI, alpha subunit
  • cow(535956) sodium channel, voltage-gated, type XI, alpha subunit
  • domestic cat(101085312) sodium channel, voltage-gated, type XI, alpha subunit
  • dog(485593) sodium channel, voltage-gated, type XI, alpha subunit
  • naked mole-rat(101723747) sodium channel, voltage-gated, type XI, alpha subunit

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Antibodies

货号
说明
物种反应性
应用
HPA036747
Anti-SCN11A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
HPA036746
Anti-SCN11A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
SAB1404926
Monoclonal Anti-SCN11A, (C-terminal) antibody produced in mouse, clone 2B10, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
S2196
抗-钠离子通道 NaV1.9 兔抗, affinity isolated antibody, lyophilized powder,
物种反应性
rat
应用
western blot
S8809
Pan单克隆抗 钠通道 小鼠抗, ~1 mg/mL, clone K58/35, purified immunoglobulin,
物种反应性
mammals
应用
immunofluorescence
immunohistochemistry
western blot

Small Molecule - Blocker

货号
说明
物种
PHR1257
利多卡因, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
1366013
利多卡因 盐酸盐, United States Pharmacopeia (USP) Reference Standard,
物种
human
P9879
普鲁卡因 盐酸盐, ≥97%,
物种
human
1366002
利多卡因, United States Pharmacopeia (USP) Reference Standard,
物种
human
PHR1034
利多卡因, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human

Small Molecule - Ligand

货号
说明
物种
L3791
拉莫三嗪, ≥98%, powder,
物种
rat, human

esiRNA

货号
说明
物种
EHU136231
MISSION® esiRNA, targeting human SCN11A,
物种
human