生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
lyophilized powder
种属反应性
rat
技术
western blot: 1:200 using rat DRG lysates
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SCN11A(11280)
mouse ... Scn11a(24046)
rat ... Scn11a(29701)
一般描述
Sodium Channel NaV1.9 is a threshold channel, that is expressed in dorsal root ganglion neurons , peripheral nociceptive neurons and visceral afferents. It is also called as SNS and NaN. It is encoded by SCN11A (sodium voltage-gated channel subunit 11) and is located on human chromosome 3p22.
免疫原
peptide CNGDLSSLDVAKVKVHND corresponding to residues 1748-1765 of rat Nav1.9. This sequence has 15/18 residues identical in mouse and 14/18 residues identical in human.
生化/生理作用
Sodium Channel NaV1.9 participates in pain at the time of inflammation. Downregulation of Nav1.9 is observed in Hirschsprung′s disease.
外形
Lyophilized from phosphate buffered saline, pH 7.4, with 1% bovine serum albumin, and 0.05% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our 产品选型工具.
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability
Huang J, et al.
The Journal of Clinical Investigation, 127(7), 2805-2814 (2017)
Decreased Nav1.9 channel expression in Hirschsprung's disease
O'Donnell AM, et al.
Journal of Pediatric Surgery, 51(9), 1458-1461 (2016)
Congenital insensitivity to pain: Fracturing without apparent skeletal pathobiology caused by an autosomal dominant, second mutation in SCN11A encoding voltage-gated sodium channel 1.9
Phatarakijnirund V, et al.
Bone, 84, 289-298 (2016)
Biology and management of histologic transformation of indolent lymphoma
Freedman AS, et al.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, 314-20 (2005)
Jianying Huang et al.
Brain : a journal of neurology, 137(Pt 6), 1627-1642 (2014-04-30)
Sodium channel Nav1.9 is expressed in peripheral nociceptive neurons, as well as visceral afferents, and has been shown to act as a threshold channel. Painful peripheral neuropathy represents a significant public health challenge and may involve gain-of-function variants in sodium
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门