GRM5
glutamate receptor, metabotropic 5
别名:
GPRC1E, MGLUR5, mGlu5
物种:
Human GRM5 (2915), Mouse Grm5 (108071), Rat Grm5 (24418), domestic guinea pig Grm5 (100714109), naked mole-rat Grm5 (101696979), chicken GRM5 (373933), domestic cat GRM5 (101091895), cow GRM5 (100336861), dog GRM5 (485146)
UniProtKB ID:
基因ID:
- Human(2915) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
- Mouse(108071) glutamate receptor, metabotropic 5
- Rat(24418) glutamate receptor, metabotropic 5
- domestic guinea pig(100714109) glutamate receptor, metabotropic 5
- naked mole-rat(101696979) glutamate receptor, metabotropic 5
- chicken(373933) glutamate receptor, metabotropic 5
- domestic cat(101091895) glutamate receptor, metabotropic 5
- cow(100336861) glutamate receptor, metabotropic 5
- dog(485146) glutamate receptor, metabotropic 5
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Small Molecule - Agonist
Small Molecule - Antagonist
Antibodies
货号
说明
物种反应性
应用
抗代谢型谷氨酸受体5抗体，疼痛, Chemicon®, from rabbit,
物种反应性
bovine, feline, horse, human, mouse, primate, rat
应用
immunohistochemistry
western blot
western blot
抗-mGluR5抗体，克隆N75/33, clone N75/33, from mouse,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-mGluR5 Antibody, clone 11D9.1, clone 11D9.1, from mouse,
物种反应性
human, rat
应用
immunohistochemistry
western blot
western blot
Monoclonal Anti-Mglur1/5 antibody produced in mouse, clone S75-33, purified immunoglobulin,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-GRM5 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Proteins
货号
说明
物种