A7275
L -2-氨基己二酸
≥98% (TLC), powder, glutamine synthetase inhibitor
别名:
( S )-2-氨基己二酸, L -高谷氨酸, 酸性激活作用结构域
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线性分子式:
HO2C(CH2)3CH(NH2)CO2H
化学文摘社编号:
分子量:
161.16
Beilstein:
1724348
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.32
产品名称
L -2-氨基己二酸, ≥98% (TLC)
质量水平
方案
≥98% (TLC)
表单
powder
mp
203-205 °C (dec.) (lit.)
SMILES字符串
N[C@@H](CCCC(O)=O)C(O)=O
InChI
1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)/t4-/m0/s1
InChI key
OYIFNHCXNCRBQI-BYPYZUCNSA-N
基因信息
human ... GLUL(2752), LGSN(51557)
rat ... Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Grm6(24419)
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一般描述
L-2-氨基己二酸/α-氨基己二酸酯是一种葡聚糖毒素，其是谷氨酰胺的结构类似物。它由赖氨酸蔗糖（SAC）/哌酸（PIP）途径的分解代谢产生。
应用
L-2-氨基己二酸已被用作大鼠星形胶质细胞特异的一种胶质毒素。它也已作为发酵食品样品氨基酸分析中的内标。
生化/生理作用
L-2-氨基己二酸可抑制谷氨酰胺合成酶和 γ-谷氨酰半胱氨酸合成酶。它可调节葡萄糖代谢，并在糖尿病患者中水平更高。L-2-氨基己二酸在抑制C2C12肌管中的自噬中起关键作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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Sun C, et al.
Frontiers in Cellular Neuroscience, 12, 2168-2175 (2018)
M E Alañón et al.
Food research international (Ottawa, Ont.), 101, 239-248 (2017-09-25)
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Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, ocaminoadipate
McBean, Gethin J
British Journal of Pharmacology, 113(2), 536-540 (1994)
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