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Merck
CN

AB5675

抗代谢型谷氨酸受体5抗体，疼痛

Chemicon®, from rabbit

别名:

Metabotropic glutamate receptor 5, Metabotropic Glutamate Receptor 5 Antibody, mGluR5, Anti-mGluR5

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关于此项目

UNSPSC代码:
12352203
eCl@ss:
32160702
NACRES:
NA.41

主要文件

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生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

纯化方式

affinity chromatography

种属反应性

rat, mouse

种属反应性（根据同源性预测）

human (based on 100% sequence homology), bovine (based on 100% sequence homology), primate (based on 100% sequence homology), horse (based on 100% sequence homology), feline (based on 100% sequence homology)

制造商/商品名称

Chemicon®

技术

immunohistochemistry: suitable
western blot: suitable

NCBI登记号

NP_001137306

UniProt登记号

Q3UVX5

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... GRM5(2915)

相关类别

一般描述

代谢型谷氨酸受体5或mGluR5（UniProt Q3UVX5；也称为G蛋白偶联受体GRM5，G蛋白偶联受体家族C，第1组，成员E）由鼠种中的Grm5（也称为Gprc1e，Mglur5，AI850523、6430542K11Rik）基因编码（基因ID 108071）。代谢型谷氨酸受体属于G蛋白偶联受体家族，根据其序列同源性，推定的信号转导机制和药理特性将其分为3类。mGluR1和mGluR5构成I类代谢型谷氨酸受体。在神经元和小胶质细胞的突触后末端发现了mGluR5。mGluR5通过Gq/G11偶联发出信号以激活磷脂酶C，从而导致钙动员和蛋白激酶C（PKC）激活。此外，据报告，mGluR5还以不依赖G蛋白的方式介导涉及Src家族蛋白酪氨酸激酶的信号传导。
观察值〜150 kDa。某些裂解液可能会出现未表征的条带。

免疫原

KLH偶联的线性肽，对应于大鼠代谢型谷氨酸受体5的细胞质域。

应用

抗代谢型谷氨酸受体5抗体，疼痛是用于IH &WB的一种针对代谢型谷氨酸受体5的抗体。
研究子类别
神经递质& 受体
研究类别
神经科学
蛋白印迹分析: 0.1-0.5 μg/mL，大鼠脑微粒体制备使用ECL。与~132 kDa的条带反应。
免疫组化：在用含15%饱和苦味酸的4%多聚甲醛的0.1 M PB、pH值7.4固定的大鼠脑和小鼠脑切片上为0.1-0.2 μg/ml。
免疫组化分析：代表性批次的1：50稀释液在小鼠后脑和大鼠结肠组织中检测到代谢型谷氨酸受体5。

生化/生理作用

该抗体不能检测亚型2。

外形

免疫亲和纯化
纯化的兔多克隆抗体，溶于含0.05％叠氮化钠的PBS缓冲液中

制备说明

自收到之日起，在 2-8°C 条件下可稳定保存1年

分析说明

对照
脑组织
通过蛋白质印迹对大鼠脑组织裂解物的微粒体制剂进行了评估。

蛋白质印迹分析：2.0 µg/mL 的该抗体在 10 µg大鼠脑组织裂解物的微粒体制剂中检测到代谢型谷氨酸受体5。

其他说明

2024年CiteAb奖，授予在帕金森研究方面取得成功的供应商
替代品：AB1596；06-451

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Pratyush S Suryavanshi et al.
Molecular pharmacology, 90(2), 96-105 (2016-05-28)
The delta family of ionotropic glutamate receptors consists of glutamate delta-1 (GluD1) and glutamate delta-2 receptors. We have previously shown that GluD1 knockout mice exhibit features of developmental delay, including impaired spine pruning and switch in the N-methyl-D-aspartate receptor subunit
Rocco G Gogliotti et al.
Human molecular genetics, 25(10), 1990-2004 (2016-03-05)
Rett syndrome (RS) is a neurodevelopmental disorder that shares many symptomatic and pathological commonalities with idiopathic autism. Alterations in protein synthesis-dependent synaptic plasticity (PSDSP) are a hallmark of a number of syndromic forms of autism; in the present work, we
Kalina Andreeva et al.
Ophthalmology and eye diseases, 6, 43-54 (2014-09-12)
Ischemia/reperfusion (IR) injury has been associated with several retinal pathologies, and a few genes/gene products have been linked to IR injury. However, the big picture of temporal changes, regarding the affected gene networks, pathways, and processes remains to be determined.
Anthony D Umpierre et al.
Experimental neurology, 279, 116-126 (2016-02-21)
More efficient or translationally relevant approaches are needed to model acquired temporal lobe epilepsy (TLE) in genetically tractable mice. The high costs associated with breeding and maintaining transgenic, knock-in, or knock-out lines place a high value on the efficiency of
Laura T Haas et al.
The Journal of biological chemistry, 289(41), 28460-28477 (2014-08-26)
Soluble Amyloid-β oligomers (Aβo) can trigger Alzheimer disease (AD) pathophysiology by binding to cell surface cellular prion protein (PrP(C)). PrP(C) interacts physically with metabotropic glutamate receptor 5 (mGluR5), and this interaction controls the transmission of neurotoxic signals to intracellular substrates.
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