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Merck
CN

A6816

（±）-AMPA

solid

别名:

(±)-α-氨基-3-羟基-5-甲基异恶唑-4-丙酸 水合物

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关于此项目

经验公式（希尔记法）:
C7H10N2O4
分子量:
186.17
NACRES:
NA.32
PubChem Substance ID:
24891141
UNSPSC Code:
12352100
MDL number:
MFCD00213388

主要文件

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InChI

1S/C7H10N2O4.H2O/c1-3-4(6(10)9-13-3)2-5(8)7(11)12;/h5H,2,8H2,1H3,(H,9,10)(H,11,12);1H2

SMILES string

O.Cc1onc(O)c1CC(N)C(O)=O

InChI key

HFISYNCCKQHIAM-UHFFFAOYSA-N

form

solid

color

white

solubility

H2O: 1 mg/mL (warm), 0.1 M HCl: 3.5 mg/mL, 0.1 M NaOH: 4.3 mg/mL, DMSO: 4.3 mg/mL, 1 M HCl: 50 mg/mL

Quality Level

200

Gene Information

rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Slc1a1(25550), Slc1a2(29482), Slc1a3(29483)

相关类别

Application

(±)-AMPA 已被用于：
  • Müller 胶质细胞的体内

  • 全细胞膜片钳记录
  • 测试其在海马切片培养物中的兴奋性毒性作用
  • 测试在视网膜水平细胞 (HC) 培养物中其对Ca2+信号的作用

Biochem/physiol Actions

强效兴奋性氨基酸，可选择性地与中枢AMPA/红藻氨酸受体相互作用。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000070063
0000070064
0000063010
0000063025
0000063014

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B W Kristensen et al.
Brain research, 917(1), 21-44 (2001-10-17)
The excitotoxic profiles of (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propionic acid (ATPA), (RS)-2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), kainic acid (KA) and N-methyl-D-aspartate (NMDA) were evaluated using cellular uptake of propidium iodide (PI) as a measure for induced, concentration-dependent neuronal damage in hippocampal slice cultures. ATPA is
Joonwoo Lee et al.
Biological & pharmaceutical bulletin, 36(3), 331-338 (2013-03-02)
Various effects of acorn extract have been reported including antioxidant activity, cytotoxicity against cancer cells, and the levels of acetylcholine and its related enzyme activities in the dementia mouse models. However, it is unclear whether acorn extract inhibits glutamate-induced calcium
Stuti J Jaiswal et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(6), 2616-2625 (2013-02-09)
Developmental nicotine exposure (DNE) impacts central respiratory control in neonates born to smoking mothers. We previously showed that DNE enhances the respiratory motor response to bath application of AMPA to the brainstem, although it was unclear which brainstem respiratory neurons
Laura A DeNardo et al.
Neuron, 76(4), 762-775 (2012-11-28)
An important organizing feature of the CNS is that individual neurons receive input from many different sources. Independent regulation of synaptic input is critical for the function and adaptive responses of the nervous system, but the underlying molecular mechanisms are not
Qin Li et al.
Brain research, 1228, 43-57 (2008-07-08)
Electrical synapses play an important role in signaling between neurons and the synaptic connections between many neurons possess both electrical and chemical components. Although modulation of electrical synapses is frequently observed, the cellular processes that mediate such changes have not
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