Hepatocyte Growth Factor (HGF)
Hepatocyte growth factor (HGF) is a potent mitogen for hepatocytes and a variety of other cells, including endothelial and epithelial cells, melanocytes, and keratinocytes. It also mediates epithelial morphogenesis. HGF is the ligand for a receptor encoded by the c-met proto-oncogene. c-Met expression has been observed in tumors from many sources, including stomach, lung, breast, kidney colon, liver, and melanoma, and is associated with tumor progression and metastasis.
Hepatocyte Growth Factor (HGF)
| Product Description | Source | Recombinant Host | Physical Form | Assay | Cell Type Affected | Product No. |
|---|---|---|---|---|---|---|
| Hepatocyte Growth Factor | human | Baculovirus infected High-5 cells | lyophilized powder | The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5. | renal tubular epithelial cell hepatocyte epidermal keratinocyte epidermal keratinocyte | H1404 |
| Hepatocyte Growth Factor | human | mouse NSO cells | lyophilized powder | The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in the HGF responsive monkey epithelial cell line, 4MBr-5. | hepatocyte epidermal keratinocyte renal tubular epithelial cell epidermal melanocyte | H9661 |
Materials
| Product No. | Product Name | Description | Pricing |
|---|---|---|---|
| NXF-10 | Natrix® Q 小试装置 | ||
| NXF-20 | Natrix® Q Process 150 | ||
| NXF-50 | Natrix® Q工艺600 |
References
1.
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF. 2003. Met, metastasis, motility and more. Nat Rev Mol Cell Biol. 4(12):915-925. https://doi.org/10.1038/nrm1261
2.
3.
Zhang Y, Vande Woude GF. 2003. HGF/SF-met signaling in the control of branching morphogenesis and invasion. J. Cell. Biochem.. 88(2):408-417. https://doi.org/10.1002/jcb.10358
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