Skip to Content
Merck
CN

FDA-approved drug labeling for the study of drug-induced liver injury.

Drug discovery today (2011-06-01)
Minjun Chen, Vikrant Vijay, Qiang Shi, Zhichao Liu, Hong Fang, Weida Tong
ABSTRACT

Drug-induced liver injury (DILI) is a leading cause of drugs failing during clinical trials and being withdrawn from the market. Comparative analysis of drugs based on their DILI potential is an effective approach to discover key DILI mechanisms and risk factors. However, assessing the DILI potential of a drug is a challenge with no existing consensus methods. We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts. The method is transparent and reproducible with a potential to serve as a common practice to study the DILI of marketed drugs for supporting drug discovery and biomarker development.

MATERIALS
Product Number
Brand
Product Description

Supelco
Ibuprofen
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Vitamin D2 solution, 100 μg/mL in ethanol, 98% (CP)
SKU
Pack Size
Availability
Price
Quantity
Supelco
Nicotinic acid, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Supelco
D-Mannitol, ≥99.9999% (metals basis), for boron determination
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Ethanolamine, puriss. p.a., ACS reagent, ≥99.0% (GC/NT)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, tested according to Ph. Eur.
SKU
Pack Size
Availability
Price
Quantity
Supelco
Ethanolamine, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Ethanolamine, ACS reagent, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
2-Mercapto-1-methylimidazole, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Nicotinic acid, ≥99.5% (HPLC)
SKU
Pack Size
Availability
Price
Quantity
Millipore
D-Mannitol, ACS reagent, suitable for microbiology, ≥99.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, BioUltra, ≥99.0% (sum of enantiomers, HPLC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Ethanolamine, ≥99%
SKU
Pack Size
Availability
Price
Quantity
Supelco
Mebendazole, VETRANAL®, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Dianhydro-D-glucitol, 98%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
2-Propylpentanoic acid
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Nicotinic acid, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Ethanolamine, liquid, BioReagent, suitable for cell culture, ≥98%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Indomethacin, meets USP testing specifications
SKU
Pack Size
Availability
Price
Quantity
Supelco
Methimazole, analytical standard
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Nicotinic acid, meets USP testing specifications
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Ibuprofen, meets USP testing specifications
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, meets EP, FCC, USP testing specifications
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Tetracycline, 98.0-102.0% (HPLC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, BioXtra, ≥98% (HPLC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
β-Estradiol, BioReagent, powder, suitable for cell culture
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, ≥98% (GC)
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, ACS reagent
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
Sulindac, ≥98.0%
SKU
Pack Size
Availability
Price
Quantity
Sigma-Aldrich
D-Mannitol, ≥98% (GC), suitable for plant cell culture
SKU
Pack Size
Availability
Price
Quantity