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Merck
CN

72309

Nicotinic acid

≥99.5% (HPLC)

Synonym(s):

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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About This Item

Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
59-67-6
Molecular Weight:
123.11
UNSPSC Code:
12352209
NACRES:
NA.26
PubChem Substance ID:
57652411
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
MFCD00006391

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Product Name

Nicotinic acid, ≥99.5% (HPLC)

Quality Level

200

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

SMILES string

OC(=O)c1cccnc1

biological source

synthetic

assay

≥99.5% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.2% water

ign. residue

≤0.05%

color

colorless to white

mp

234-238 °C
236-239 °C (lit.)

solubility

water: 0.1 g/10 mL, clear, colorless

density

1.473 g/cm3 at 25 °C

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Application

Nicotinic acid has been used as a standard in NAD+ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.

Biochem/physiol Actions

Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.

General description

Nicotinic acid, also referred as Niacin or vitamin B3, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.

Other Notes

Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL5256
BCCL7918
BCCJ4764
BCCJ6557
BCCG2139

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