Skip to Content
Merck
CN
All Photos(1)

Documents

72309

Sigma-Aldrich

Nicotinic acid

≥99.5% (HPLC)

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3
Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
59-67-6
Molecular Weight:
123.11
Beilstein:
109591
EC Number:
200-441-0
MDL number:
MFCD00006391
UNSPSC Code:
12352209
PubChem Substance ID:
57652411
NACRES:
NA.26

biological source

synthetic

Quality Level

200

Assay

≥99.5% (HPLC)

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

≤0.2% water

ign. residue

≤0.05%

color

colorless to white

mp

234-238 °C
236-239 °C (lit.)

solubility

water: 0.1 g/10 mL, clear, colorless

density

1.473 g/cm3 at 25 °C

SMILES string

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

Looking for similar products? Visit Product Comparison Guide

Related Categories

General description

Nicotinic acid, also referred as Niacin or vitamin B3, is a water soluble vitamin. It is present in vitamin-enriched bread, liver, meat, fish, poultry, potatoes, green vegetables, peanuts and cereals.

Application

Nicotinic acid has been used as a standard in NAD+ precursor rescue experiments. It has also been used as a vitamin supplement in various culture media such as complete medium (CM) and synthetic medium.

Biochem/physiol Actions

Nicotinic acid or Niacin regulates lipid metabolism by reducing low density lipoprotein (LDL), increasing high-density lipoprotein (HDL) and by inhibiting the progression of atherosclerosis and coronary artery lesions. Niacin deficiency leads to pellagra. In addition to vitamin supplement, niacin is also used as a broad spectrum lipid drug.

Other Notes

Coenzyme and Cofactors, vol 2: Pyridine Nucleotide Coenzymes

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Hazard Classifications

Eye Irrit. 2

WGK

WGK 1

Flash Point(F)

379.4 °F

Flash Point(C)

193 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

D.Dolphin, R.Poulson, O.Avramovic, eds.
Chemical, Biochemical and Medical Aspects, 759-759 (1987)
Nicotinic Acid Regulates Glucose and Lipid Metabolism Through Lipidindependent Pathways
Liu D, et al.
Current Pharmaceutical Biotechnology, 16(1), 3-10 (2015)
Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review
Carlson LA
Journal of Internal Medicine, 258(2), 94-114 (2005)
Chemical, Biochemical and Medical Aspects, 776-776 null
NAMPT-mediated NAD+ biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin sensitivity in mice
Stromsdorfer KL, et al.
Testing, 16(7), 1851-1860 (2016)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service