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Merck
CN

N4126

Nicotinic acid

≥98%

Synonym(s):

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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About This Item

Empirical Formula (Hill Notation):
C6H5NO2
CAS Number:
59-67-6
Molecular Weight:
123.11
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
24897668
EC Number:
200-441-0
Beilstein/REAXYS Number:
109591
MDL number:
MFCD00006391

Key Documents

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Product Name

Nicotinic acid, ≥98%

InChI key

PVNIIMVLHYAWGP-UHFFFAOYSA-N

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

SMILES string

OC(=O)c1cccnc1

biological source

synthetic (organic)

assay

≥98%

form

powder

color

white to off-white

mp

236-239 °C (lit.)

Quality Level

200

Gene Information

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Application

Nicotinic acid has been used:
  • as a component of the MS vitamins stock solution
  • for the detection of siderophores in Escherichia coli bacterial culture
  • as a component of the holidic medium for adult Drosophila .

Biochem/physiol Actions

Niacin is involved in the production of nicotinamide adenine dinucleotide (NAD+), which is used in the adenine triphosphate (ATP) production in mitochondrial oxidative phosphorylation. It also decreases hepatic production of very-low density lipoproteins (VLDL), and apolipoprotein B (apo-B). Niacin deficiency leads to pellagra.

General description

Nicotinic acid is also known as vitamin B3 or Niacin. It is a water soluble vitamin. Niacin can be either synthesized within the body or can be obtained from dietary sources.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

379.4 °F - closed cup

flash_point_c

193 °C - closed cup

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000521138
0000521136
0000521137
0000521137
0000521136

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Vitamin B3 and sirtuin function
Denu J M
Trends in Biochemical Sciences, 30(9), 479-483 (2005)
Variation in availability of niacin in grain products
Wall JS and Carpenter KJ
Food Technology (1988)
An investigation into the pathogenic properties of Escherichia coli strains BLR, BL21, DH5 alpha and EQ1
Chart H, et al.
Journal of Applied Microbiology, 89(6), 1048-1058 (2000)
A holidic medium for Drosophila melanogaster
Piper M D W, et al.
Nature Methods, 11(1), 100-100 (2014)
A procedure allowing up to eight generations of wheat and nine generations of barley per annum
Zheng Z, et al.
Euphytica, 191(2), 311-316 (2013)
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胆固醇的运输

由于胆固醇是水不溶性分子，必须包装后才能在血浆中运输。包装胆固醇、胆固醇酯和甘油三酯以便运输的颗粒称为脂蛋白。

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