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33085

Supelco

Acetic anhydride

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About This Item

Linear Formula:
(CH3CO)2O
CAS Number:
108-24-7
Molecular Weight:
102.09
Beilstein:
385737
EC Number:
203-564-8
MDL number:
MFCD00008705
UNSPSC Code:
41116105
PubChem Substance ID:
329754454

grade

for GC derivatization

vapor density

3.5 (vs air)

vapor pressure

10 mmHg ( 36 °C)
4 mmHg ( 20 °C)

autoignition temp.

629 °F

expl. lim.

10.3 %

packaging

pkg of 10 × 2 mL

refractive index

n20/D 1.390 (lit.)

bp

138-140 °C (lit.)

mp

−73 °C (lit.)

solubility

H2O: slightly soluble

density

1.08 g/mL (lit.)

SMILES string

CC(=O)OC(C)=O

InChI

1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3

InChI key

WFDIJRYMOXRFFG-UHFFFAOYSA-N

General description

Acetic anhydride (CH3CO)2O, also known as ethanoric anhydride, is a colorless liquid with a strong pungent odor. It has a boiling point of 140°C (284°F). It is soluble in cold water, decomposes in hot water to form acetic acid, and is soluble in alcohol, chloroform and ether. It is a highly corrosive flammable liquid with harmful vapour. Exposure to acetic anhydride can occur via eye or skin contact, ingestion and inhalation.

Application

Suitable for the derivatization of acetaminophen, alcohols, amines, amino acids, arginyl peptides, aryl sulfate esters, carbamates, cerebrosides, cystine and cysteine (in peptides), desmethyldoxepin, 3,4-dihydroxyphenylglycol, hydroxamic acids, hydroxyamines, n-hydroxycarbamates, 4-methoxy and 3,4-dimethoxyphenethylamine, nucleosides bases and sugars, peptides, phenolalkylamines, phenylethylamines, phenylthiohydantoin amino acid, serotonin, and tryptamines.

Other Notes

Reagent for acetyl, o-acetyl, N-acetyl-N, permethyl acetyl, aryl acetate, ß-carboline, methyl ester, acetyl or trifluoroacetyl phenylthihydantoins, n-trifluoroacetyl, bis-trimethylsilyl, trimethylsilyl polyamino alcohol, and O-trimethylsilyl (TMS).

related product

Product No.
Description
Pricing

Signal Word

Danger

Hazard Statements

H226,H302,H314,H330

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B

WGK

WGK 1

Flash Point(F)

closed cup

Flash Point(C)

closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
LC24436V
LC21761V
LC20088V
LC13136V
LC09249V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. What is the advantage of acylation compared to silylation?

    Acylation, an alternative to silylation, produces stable, volatile derviatives of phenols, alcohols, and amines for analysis by GC/FID.  Acylated compounds are more stable than their corresponding silylated compounds.  

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Handbook of Corrosion Data.
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Technology & Engineering, 108-109 (1994)
J M Mee et al.
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