91204
Acetic anhydride
for GC derivatization, LiChropur™, ≥99.0%
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Linear Formula:
(CH3CO)2O
CAS Number:
Molecular Weight:
102.09
Beilstein:
385737
EC Number:
MDL number:
UNSPSC Code:
12000000
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
grade
for GC derivatization
Quality Level
vapor density
3.5 (vs air)
vapor pressure
10 mmHg ( 36 °C)
4 mmHg ( 20 °C)
Assay
≥99.0% (GC)
≥99.0%
form
liquid
autoignition temp.
629 °F
quality
LiChropur™
expl. lim.
10.3 %
reaction suitability
reagent type: derivatization reagent
reaction type: Acylations
technique(s)
gas chromatography (GC): suitable
evapn. residue
≤0.003%
refractive index
n20/D 1.390 (lit.)
bp
138-140 °C (lit.)
mp
−73 °C (lit.)
solubility
H2O: slightly soluble
density
1.08 g/mL (lit.)
SMILES string
CC(=O)OC(C)=O
InChI
1S/C4H6O3/c1-3(5)7-4(2)6/h1-2H3
InChI key
WFDIJRYMOXRFFG-UHFFFAOYSA-N
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General description
Acetic anhydride is an esterification agent which is corrosive to metals. It is a colourless liquid with strong vinegar-like odour. It is mostly used in making plastics, fibers, pharmaceuticals, dyes and explosives.
Acylation, an alternative to silylation, enables the conversion of compounds that comprise of active hydrogens (-OH, -SH and -NH) into esters, thioesters, and amides by the action of a carboxylic acid or derivative. The carbonyl group adjacent to the halogenated carbons favors the improvement of electron capture detector (ECD) response. Acylation has several benefits:
Acetic anhydride is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
- It increases the stability of compounds by protecting unstable groups.
- It may render volatility on substances like carbohydrates or amino acids, that have several polar groups that they are non-volatile and generally decompose on heating.
- It allows the separations not possible with underivatized compounds.
- Compounds are detectable at very low levels with an ECD.
Acetic anhydride is a reagent utilized to form fragmentation-directing derivatives for GC/MS analysis.
Application
Learn more in the Product Information
Suitable for the derivatization of acetyl, acetaminophen, alcohols, aldoses and partially methylated aldoses, aldosterone, amines, amino acids, amino sugars (in polysaccharides), amino sugar methyl glycosides, 2-amino-2-deoxyhexoses, arginyl peptides, aryl sulfate esters, bile acids, carbamates, carbohydrates, cerebrosides, cystine and cysteine (in peptides), desmethyldoxepin, 3,4-dihydroxyphenylglycol, estrogens, glycitols, hexopyranosides, hexosamines, hydroxamic acids, hydroxyamines, n-hydroxycarbamates, hydroxy steroids, inositols, 4-methoxy and 3,4-dimethoxyphenethylamine, methyl ester, methyl(methyl O-methyl-a-D-glucopyranosid)uronates, nucleosides, nucleoside bases and sugars, partially methylated pentose and hexoes, peptides, phenolalkylamines, phenylethylamines, polysaccharide constituents, postaglandins A,B and E, serotonin, sialic acids, sugars, natural sugars and tryptamine.
Other Notes
Reagent for acetic anhydride, acetyl, n-acetyl, n-acetyl-n, o-acetyl, acetate, aldononitrile acetate, aminoglycitol acetate, aryl acetate, permethyl acetyl, methyl ester, trifluoroacetyl, bis-trimethylsilyl, trimethylsilyl polyamino alcohol, and O-trimethylsilyl (TMS).
Legal Information
LiChropur is a trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
WGK
WGK 1
Flash Point(F)
closed cup
Flash Point(C)
closed cup
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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