T2815
Transforming Growth Factor-β2 human
TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture
Synonym(s):
hTGF-β2, TGF-β2
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
biological source
human
Quality Level
recombinant
expressed in NSO cells
Assay
≥97% (electrophoresis)
form
powder
potency
0.04 ng/mL ED50
quality
endotoxin tested
mol wt
25 kDa
packaging
pkg of 10 μg
pkg of 2 μg
storage condition
avoid repeated freeze/thaw cycles
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
suitability
suitable for
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TGFB2(7042) , TGFBR2(7048)
Looking for similar products? Visit Product Comparison Guide
Related Categories
General description
The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41. The encoded protein is localized to extracellular matrix. TGF-β2 is a member of the TGF-β superfamily. TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.
Application
Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells. It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.
Biochem/physiol Actions
TGF-β2 is known to stimulate cell growth, differentiation, migration and survival. TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis. TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells. TGF-β is associated with the process of tumor development, progression and metastasis. TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.
Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin
Analysis Note
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
新产品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Tetramethylpyrazine (TMP), an Active Ingredient of Chinese Herb Medicine Chuanxiong, Attenuates the Degeneration of Trabecular Meshwork through SDF-1/CXCR4 Axis
Yu N, et al.
PLoS ONE, 10.8 (2015)
TGF-β2?induced matrix modification and cell transdifferentiation in the human lens capsular bag
Wormstone IM, et al.
Investigative Ophthalmology & Visual Science, 43.7, 2301-2308 (2002)
Michael S Oldenburg et al.
The Laryngoscope, 128(1), 160-167 (2017-09-13)
Design and test a novel biomaterial for injection laryngoplasty aimed to increase the duration of effectiveness of micronized acellular dermis. Animal model. Injection laryngoplasty was performed in three groups (n = 5) of New Zealand White rabbits. Acellular dermis was
Preliminary Results of Tissue-Engineered Injection Laryngoplasty
Material in a Rabbit Model
Material in a Rabbit Model
Oldenburg MS, et al.
Laryngoscope, 128, 160-167 (2018)
Transforming growth factor β (TGF-β) and inflammation in cancer.
Bierie B and Moses HL
Cytokine & Growth Factor Reviews, 21.1, 49-59 (2010)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service