SRP6309
Proteinase 3 from human neutrophils
≥95% (SDS-PAGE)
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Synonym(s):
AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
UNSPSC Code:
12352200
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biological source
human
Assay
≥95% (SDS-PAGE)
form
frozen liquid
mol wt
29 kDa
packaging
pkg of 25 μg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AGP7(5657)
General description
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by α1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation. Proteinase 3 (PR-3) is also known as myeloblastin and p29b.
Physical form
Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
Certificates of Analysis (COA)
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