All Photos(1)
Synonym(s):
AGP7, Myeloblastin, P29B, PR-3, PR3 Ag
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
Assay
≥95% (PAGE)
form
buffered aqueous solution
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PRTN3(5657)
General description
Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4
Application
Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2
Biochem/physiol Actions
Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3
Used for the detection of anti-PR3 auto-antibodies in immunoassays.
Physical form
Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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