E3539
Proteinase 3 from human leukocytes
≥95% (PAGE)
Synonym(s):
AGP7, Myeloblastin, P29B, PR-3, PR3 Ag
assay
≥95% (PAGE)
form
buffered aqueous solution
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... PRTN3(5657)
General description
Proteinase 3 is found in high concentration in the primary granules of myeloid leukemia blasts.4
Application
Proteinase 3 has been shown to be important in the pathogenesis of human emphysema.1 It has also been used in a study to investigate the liberation of the antibacterial and cytotoxic peptide LL-37 by cleavage of human cathelicidin hCAP-183.2
Biochem/physiol Actions
Used for the detection of anti-PR3 auto-antibodies in immunoassays.
Proteinase 3 (PR-3) is a serine protease expressed in the granules of neutrophils and monocytes. Also known as myeloblastin and p29b, it degrades elastin and is associated with myeloid leukemia and Wegener′s granulomatosis.3
Physical form
Solution in 50 mM sodium acetate (pH 5) with 600 mM sodium chloride
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
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