SRP6267
C-reactive/CRP human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
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Synonym(s):
C-reactive protein, CRP, PTX1
UNSPSC Code:
12352202
NACRES:
NA.32
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biological source
human
recombinant
expressed in HEK 293 cells
tag
6-His tagged (C-terminus)
Assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
calculated mol wt 24 kDa
observed mol wt 26 kDa (DTT-reduced. Phe17 is the predicted N-terminus.)
packaging
pkg of 100 μg
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CRP(1401)
General description
C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat, respectively.
Biochem/physiol Actions
CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.
Physical form
Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease.
Verma S
Circulation, 109, 2058-2067 (2004)
Yeongseok Jang et al.
Nanoscale, 12(18), 9980-9990 (2020-03-05)
We present multiple-bent multi-walled carbon nanotubes (MWCNTs) that enable the picomolar detection of C-reactive protein (CRP), which is considered to be a promising biomarker for various diseases. The MWCNTs were grown via chemical vapor deposition repeating the asymmetric catalytic CNT
Human C-reactive protein: expression, structure, and function.
Volanakis JE
Molecular Immunology, 38, 189-197 (2001)
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