236603
C-Reactive Protein, Human Serum, High Purity
C-Reactive Protein, Human Serum, High Purity, CAS 9007-41-4, is a major acute-phase plasma protein. Useful as a calibration standard for assays of CRP and as an antigen for production of antisera.
Synonym(s):
C-Reactive Protein, Human Serum, High Purity, CRP
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About This Item
Quality Level
Assay
≥99% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−70°C
Related Categories
General description
M.W. 23,000 (monomer); 115,000 (pentamer).
Native C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera.Calibrated by electroimmunoassay against WHO reference standard or equivalent.
No reaction in ODD and Laurell electroimmunoassay against polyvalent antiserum to normal human serum, antiserum to pooled effusion fluids and monospecific antiserum to human IgG.
Warning
Toxicity: Standard Handling (A)
Physical form
In 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
Preparation Note
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-70°C).
Other Notes
Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol.24, 975.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
Certificates of Analysis (COA)
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Dobrin Nedelkov
Analytical chemistry, 79(15), 5987-5990 (2007-06-26)
Protein microarrays are the format of choice for high-throughput, high-content protein interaction analysis. In most of the array formats, reporter molecules are used in multistep detection of the protein interactions. Among the few existing label-free detection approaches, surface plasmon resonance
Elaine Paffen et al.
Arteriosclerosis, thrombosis, and vascular biology, 24(5), 975-981 (2004-03-27)
It is generally assumed that C-reactive protein (CRP) induces synthesis of tissue factor (TF) in monocytic cells, thereby potentially initiating intravascular blood coagulation. We aimed to elucidate the mechanism of CRP-induced TF expression in monocytes and monocyte-derived macrophages (MDMs) in
M Hundt et al.
European journal of immunology, 31(12), 3475-3483 (2001-12-18)
The classic acute-phase reactant C-reactive protein (CRP) plays an important role in innate immunity. Specific CRP receptors have been described on white blood cells and were further characterized as Fcgamma receptors I and II. Here, we used biotinylated, highly purified
B D Salkeld et al.
Neuroimmunomodulation, 9(6), 319-325 (2002-06-05)
This study examined the hypothesis that oral contraceptives (OC) influence the production of thermoregulatory cytokines, i.e. interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), soluble glycoprotein 130 (s-gp130) and leptin, and that OC-induced changes in oral temperature (T(oral)) are associated with changes
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