Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

For important updates on recent policy changes, please click here for more details.

Merck
CN
All Photos(1)

Key Documents

View All Documentation

SML3562

Sigma-Aldrich

TPC2-A1-N

≥98% (HPLC)

Synonym(s):

2-Cyano-3-(3,5-dichlorophenyl)-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide, TPC2 agonist N19

Sign Into View Organizational & Contract Pricing

Select a Size

5 MG
CN¥2,520.43
25 MG
CN¥10,117.38

CN¥2,520.43

Please contact Customer Service for Availability
Request a Bulk Order
All Photos(1)

Select a Size

Change View
5 MG
CN¥2,520.43
25 MG
CN¥10,117.38

About This Item

Empirical Formula (Hill Notation):
C17H9Cl2F3N2O2
CAS Number:
136186-07-7
Molecular Weight:
401.17
MDL number:
MFCD32878270
UNSPSC Code:
12352200
NACRES:
NA.77

CN¥2,520.43

Please contact Customer Service for Availability
Request a Bulk Order

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(/C(C#N)=C(O)/C1=CC(Cl)=CC(Cl)=C1)NC2=CC=C(C=C2)C(F)(F)F

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
SML3325SML2880SML1677
TPC2-A1-N ≥98% (HPLC)

SML3562

TPC2-A1-N

Sob-AM2 ≥98% (HPLC)

SML3325

Sob-AM2

SGC-CLK-1 ≥98% (HPLC)

SML2880

SGC-CLK-1

Tarocin A1 ≥98% (HPLC)

SML1677

Tarocin A1

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear (Warmed)

solubility

DMSO: 20 mg/mL, clear

color

white to beige

color

white to beige

color

white to beige

color

white to beige

Biochem/physiol Actions

Selective two pore segment channel 2 (TCP2) agonist that preferentially mimics the Ca2+ signals-inducing action of NAADP.
TPC2-A1-N is a selective two pore segment channel 2 (TCP2) agonist that mimics the action of NAADP where it selectively induces fast Ca2+ signals (EC50 = 7.8 µM) in a TCP2-dependent manner, without potency toward TRPML1/2/3. In contrast, TPC2-A1-N is a much weaker Na+ current inducer when compared to PI(3,5)P2 and TPC2-A1-P. TPC2-A1-N, but not the Na+ signals agonist TPC2-A1-P causes TPC2-dependent alkalinization of lysosomal lumen Ca2+ stores (10 µM, TPC2-expressing HeLa cells), while TPC2-A1-P, but not TPC2-A1-N, activates TPC2-dependent lysosomal exocytosis (30 µM, murine macrophages).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

    • Choose from one of the most recent versions:

    Certificates of Analysis (COA)

    Lot/Batch Number
    0000206991
    0000206990
    0000202497
    0000206990
    0000206991

    Don't see the Right Version?

    If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

    Search for a COA

    Already Own This Product?

    Find documentation for the products that you have recently purchased in the Document Library.

    Visit the Document Library

    Ramona Schütz et al.
    Archiv der Pharmazie, 353(7), e2000106-e2000106 (2020-05-26)
    The first racemic total synthesis of the isoquinoline-benzylisoquinoline alkaloid muraricine is reported herein. Pharmacological characterization identified muraricine as a moderate inhibitor of P-glycoprotein, a crucial factor of multidrug resistance in cancer. When combined with vincristine, muraricine partly reversed the chemoresistance of
    The lysosomotrope GPN mobilises Ca2+ from acidic organelles
    Journal of Cell Science, 134 (2021)
    The ethoxycarbonyl group as both activating and protective group in N-acyl-Pictet-Spengler reactions using methoxystyrenes. A short approach to racemic 1-benzyltetrahydroisoquinoline alkaloids
    Beilstein Journal of Organic Chemistry, 17 (2021)
    Gene editing and synthetically accessible inhibitors reveal role for TPC2 in HCC cell proliferation and tumor growth
    Cell Chemical Biology, 28 (2021)
    Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors
    Scientific Reports, 11 (2021)
    View All Related Papers

    Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

    Contact Technical Service