SML2880
SGC-CLK-1
≥98% (HPLC)
Synonym(s):
N-(3-Methoxy-5-(trifluoromethyl)phenyl)-4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine
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About This Item
Empirical Formula (Hill Notation):
C19H15F3N6O2
CAS Number:
Molecular Weight:
416.36
UNSPSC Code:
12352200
NACRES:
NA.77
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
SMILES string
FC(F)(F)C1=CC(OC)=CC(NC2=NC=CC(C3=C(C=C4)N(N=C3)N=C4OC)=N2)=C1
Biochem/physiol Actions
SGC-CLK-1 is a potent and selective CLK1/2/4 inhibitor (IC50 = 13/4/46 nM by enzyme assay; IC50 = 165/70/100 nM by cell-based NanoBRET assay) with good kinome-wide selectivity (by 403-panel KINOMEscan). SGC-CLK-1 inhibits CLK3 at significantly higher concentrations (IC50 = 363 nM by enzyme assay) and causes only partial STK16 inhibition by cell-based NanoBRET assay.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4
bioRxiv : the preprint server for biology (2022)
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