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Merck
CN

SML3219

Tenofovir alafenamide

≥98% (HPLC), HIV and HBV reverse transcriptase inhibitor, powder

Synonym(s):

9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]-methoxy]-propyl]adenine, GS 7340, GS-7340, GS7340, TAF

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About This Item

Empirical Formula (Hill Notation):
C21H29N6O5P
CAS Number:
379270-37-8
Molecular Weight:
476.47
NACRES:
NA.77
UNSPSC Code:
51111800
MDL number:
MFCD28976050

Key Documents

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Product Name

Tenofovir alafenamide, ≥98% (HPLC)

InChI

1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1

SMILES string

CC(OC([C@@H](N[P@](CO[C@@H](CN1C2=NC=NC(N)=C2N=C1)C)(OC3=CC=CC=C3)=O)C)=O)C

InChI key

LDEKQSIMHVQZJK-CAQYMETFSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

HIV and HBV reverse transcriptase inhibitor tenofovir isopropylalaninyl phenyl ester with greater antiviral efficacy than tenofovir disoproxil fumarate.
Tenofovir alafenamide (TAF; GS-7340) is an isopropylalaninyl phenyl ester prodrug of the nucleotide analog reverse transcriptase inhibitor (nRTI) tenofovir (TFV) against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). GS-7340 more efficiently delivers TFV into lymphoid cells and tissues than tenofovir disoproxil fumarate (TDF), resulting in greater antiviral efficacy against HIV.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000443053
0000443054
0000443053
0000443054
0000350770

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