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Safety Information

SH3031

Sigma-Aldrich

MISSION® shRNA Human Gene Family Set, Lentiviral Particles

Epigenetic Regulators

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2 L
CN¥3,207.82
4 X 4 L
CN¥16,804.89

CN¥3,207.82

Available to ship onApril 14, 2025Details

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2 L
CN¥3,207.82
4 X 4 L
CN¥16,804.89

About This Item

UNSPSC Code:
41106609
NACRES:
NA.51

CN¥3,207.82

Available to ship onApril 14, 2025Details

Request a Bulk OrderRequest more information

product line

MISSION®

storage temp.

−70°C

Gene Information

human ... CA1(759) , DNMT1(1786) , DNMT3A(1788) , DNMT3B(1789) , DNMT3L(29947) , MGMT(4255) , N6AMT1(29104) , N6AMT2(221143) , SPEM1(374768) , TRDMT1(1787)

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1 of 4

This Item
12622575892B1375
铬变酸 二钠盐 二水合物 puriss. p.a., ACS reagent, for the detection of Ag, ClO3-, Cr, Hg, NO2-, NO32-, Ti, ≥98.0%

27150

铬变酸 二钠盐 二水合物

铬变酸 二钠盐 二水合物 technical grade

126225

铬变酸 二钠盐 二水合物

α-酮戊二酸 二钠盐 二水合物 ≥98.0% (dried material, NT)

75892

α-酮戊二酸 二钠盐 二水合物

红菲绕啉二磺酸 二钠盐 水合物 ≥95%

B1375

红菲绕啉二磺酸 二钠盐 水合物

assay

≥98.0%

assay

≥78.5%

assay

≥98.0% (dried material, NT)

assay

≥95%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

grade

ACS reagent, puriss. p.a.

grade

technical grade

grade

-

grade

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

-

mp

300 °C (lit.)

impurities

8-10% water

impurities

-

impurities

~16% water

impurities

-

General description

Lentiviral particles (representational, plate titer) are provided in 96-well plates that are barcoded for simple identification. Aliquots of 4 x 50μl are provided to prevent the need for excessive freeze/thaw, and maximize functional viral particles. Each gene family set is representationally titered (10% of clones). Fully titered sets are also available, for more information inquire at RNAi@sial.com. A CD containing RefSeq, gene description, gene symbol, clone ID, hairpin sequence, locus link, and plate map positions are provided with the gene family set.

Other Notes

Each MISSION shRNA clone is constructed within the lentivirus plasmid vector, pLKO.1-Puro, followed by transformation into Escherichia coli. The pLKO.1-Puro vector contains bacterial (ampicillin) and mammalian (puromycin) antibiotic resistance genes for selection of inserts in either bacterial or mammalian cell lines. Each clone set consists of an average of 3-5 constructs that have been designed against each target gene using a proprietary algorithm. Therefore, a range of knockdown efficiency, with at least one construct from each gene set being >70%, can be expected when using these clones. This allows one to examine the effect of loss of gene function over a large series of gene knockdown efficiencies. Each shRNA construct has been cloned and sequence verified to ensure a match to the target gene.
For a detailed listing of other available gene family sets, visit the gene family set website.
Number of Genes: 11, Number of Clones: 57
The exact gene and clone count at time of purchase may vary slightly as the TRC library is continually updated.

Legal Information

Use of this product is subject to one or more license agreements. For details, please see http://sigmaaldrich.com/missionlicense .
MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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    Epigenetics in cancer.
    Manel Esteller
    The New England journal of medicine, 358(11), 1148-1159 (2008-03-14)
    Kirsten Grønbaek et al.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 115(10), 1039-1059 (2007-11-29)
    A cancer develops when a cell acquires specific growth advantages through the stepwise accumulation of heritable changes in gene function. Basically, this process is directed by changes in two different classes of genes: Tumor suppressor genes that inhibit cell growth
    Joshua P Klopper et al.
    Molecular cancer, 8, 16-16 (2009-03-10)
    Metastatic melanoma has a high mortality rate and suboptimal therapeutic options. Molecular targeting may be beneficial using the rexinoid LGD1069, a retinoid x receptor selective agonist, and thiazolidinediones (TZD), PPARgamma selective ligands, as novel treatments. Mouse xenograft models with human
    Courtney G Woods et al.
    Toxicology and applied pharmacology, 238(1), 27-36 (2009-04-21)
    Hypochlorous acid (HOCl) is potentially an important source of cellular oxidative stress. Human HOCl exposure can occur from chlorine gas inhalation or from endogenous sources of HOCl, such as respiratory burst by phagocytes. Transcription factor Nrf2 is a key regulator

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