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Safety Information

SAB4502602

Sigma-Aldrich

Anti-CYCLIN D1, C-Terminal antibody produced in rabbit

affinity isolated antibody

Synonym(s):

BCL-1 oncogene, BCL1, CYL-1, G1/S-specific cyclin D1, cyclin D1

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About This Item

MDL number:
MFCD00239664
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 33 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P24385

UniProt accession no.

P24385

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CCND1(595)

General description

Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein.
The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3.

Immunogen

The antiserum was produced against synthesized peptide derived from human Cyclin D1.

Immunogen Range: 246-295

Application

Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis.

Biochem/physiol Actions

CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
210417

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Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects.
Lanza C
Cell Cycle, 15(10), 1363-1375 (2016)
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Hui AB
Cancer Research, 65(18), 8125-8133 (2005)
Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.
Phan B
Oncotarget, 7(15), 19519-19530 (2016)
The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.
Xie M
Medicine, 96(42), 1-9 (2017)
Chris Lanza et al.
Cell cycle (Georgetown, Tex.), 15(10), 1363-1375 (2016-04-14)
Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in
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