SAB4502021
Anti-NOTCH2 (Cleaved-Ala1734) antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
Motch B, NOTC2, NOTCH2, NTC2, Neurogenic locus notch homolog protein 2 precursor
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 79 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
proteolytically cleaved (Ala1734)
Gene Information
human ... NOTCH2(4853)
General description
The NOTCH2 (notch 2) gene is mapped to human chromosome 1p12. Anti-NOTCH2 (cleaved-Ala1734) antibody detects endogenous levels of fragment of activated NOTCH2 (cleaved-Ala1734) protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human NOTCH2.
Immunogen Range: 1715-1764
Immunogen Range: 1715-1764
Biochem/physiol Actions
The NOTCH2 (notch2) gene is known to be involved in the proliferation and cell cycle progression in cancer cells. Upregulation of the gene is observed in salivary adenoid cystic carcinoma, and hepatocellular carcinoma. Deletion of NOTCH2 offers tumor cells resistance to chemotherapeutic agents such as 5-fluorouracil. NOTCH2 plays an important role in the regulation of liver development. The NOTCH2 gene is associated with the development of diabetic nephropathy.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Certificates of Analysis (COA)
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NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
McDaniell R, et al.
American Journal of Human Genetics, 79(1), 169-173 (2006)
Altered expression of WFS1 and NOTCH2 genes associated with diabetic nephropathy in T2DM patients
Sharaf SA, et al.
Diabetes Research and Clinical Practice, 140, 304-313 (2018)
Notch2 is a crucial regulator of self-renewal and tumorigenicity in human hepatocellular carcinoma cells
Wu WR, et al.
Oncology Reports, 36(1), 181-188 (2016)
Jing Qu et al.
Molecular and cellular biochemistry, 411(1-2), 135-141 (2015-10-03)
Many studies have explored whether the Notch signaling pathway has a tumor-suppressive or an oncogenic role in various tumors; however, the role of the Notch signaling pathway in salivary adenoid cystic carcinoma (SACC) is still unknown. In this study, we
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