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SAB4500423

Sigma-Aldrich

Anti-ADORA2A antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
ADORA2, ADORA2A, Adenosine receptor A2a
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 44 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P29274

UniProt accession no.

P29274

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADORA2A(135)

General description

Anti-ADORA2A Antibody detects endogenous levels of total ADORA2A protein.
Adenosine A2a receptor (ADORA2A) is a G protein-coupled receptor. It is highly expressed in the brain. It is located on human chromosome 22q11.23.

Immunogen

The antiserum was produced against synthesized peptide derived from human ADORA2A.

Immunogen Range: 321-370

Biochem/physiol Actions

Activation of the adenosine A2a receptor (ADORA2A) prevents T-cell proliferation and production of pro-inflammatory cytokines. It functions in increasing cytosolic cAMP levels. The protein has been associated with stimulation of liver ischemic preconditioning. ADORA2A is also linked to dermal fibrosis and scleroderma.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Adenosine A2A receptor (A2AR) is a fine-tune regulator of the collagen1:collagen3 balance
Perez-Aso M, et al.
Purinergic Signaling, 9(4), 573-583 (2013)
A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease
Dhaenens CM, et al.
Neurobiology of Disease, 35(3), 474-476 (2009)
Pharmacological Preconditioning by Adenosine A2a Receptor Stimulation: Features of the Protected Liver Cell Phenotype
Alchera E, et al.
BioMed Research International (2015)
Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.
Freitag CM
European Child & Adolescent Psychiatry, 19(1), 67-74 (2010)
[Adenosine A2A receptor as a drug target for treatment of sepsis]
Sivak KV, et al.
Molekuliarnaia Biologiia, 50(2), 231-245 (2016)

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